Maintaining healthy mitochondria is mandatory for muscle viability and function. An essential surveillance mechanism targeting defective and harmful mitochondria to degradation is the selective form of autophagy called mitophagy. Ambra1 is a multifaceted protein with well-known autophagic and mitophagic functions. However, the study of its role in adult tissues has been extremely limited due to the embryonic lethality caused by full-body Ambra1 deficiency.

Ambra1 deficiency impairs mitophagy in skeletal muscle / Gambarotto, Lisa; Metti, Samuele; Chrisam, Martina; Cerqua, Cristina; Sabatelli, Patrizia; Armani, Andrea; Zanon, Carlo; Spizzotin, Marianna; Castagnaro, Silvia; Strappazzon, Flavie; Grumati, Paolo; Cescon, Matilde; Braghetta, Paola; Trevisson, Eva; Cecconi, Francesco; Bonaldo, Paolo. - In: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE. - ISSN 2190-6009. - 13:4(2022), pp. 2211-2224. [10.1002/jcsm.13010]

Ambra1 deficiency impairs mitophagy in skeletal muscle

Grumati, Paolo;
2022

Abstract

Maintaining healthy mitochondria is mandatory for muscle viability and function. An essential surveillance mechanism targeting defective and harmful mitochondria to degradation is the selective form of autophagy called mitophagy. Ambra1 is a multifaceted protein with well-known autophagic and mitophagic functions. However, the study of its role in adult tissues has been extremely limited due to the embryonic lethality caused by full-body Ambra1 deficiency.
2022
Ambra1 deficiency impairs mitophagy in skeletal muscle / Gambarotto, Lisa; Metti, Samuele; Chrisam, Martina; Cerqua, Cristina; Sabatelli, Patrizia; Armani, Andrea; Zanon, Carlo; Spizzotin, Marianna; Castagnaro, Silvia; Strappazzon, Flavie; Grumati, Paolo; Cescon, Matilde; Braghetta, Paola; Trevisson, Eva; Cecconi, Francesco; Bonaldo, Paolo. - In: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE. - ISSN 2190-6009. - 13:4(2022), pp. 2211-2224. [10.1002/jcsm.13010]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/899905
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 10
social impact