Yellow fever virus (YFV) is a mosquito-borne flavivirus, endemic in 47 countries in Africa and South America, which causes febrile symptoms that can evolve in 15% of the patients to serious hemorrhagic conditions, liver injury, and multiorgan failure. Although a highly effective vaccine (YF-17D vaccine) is available, to date, no antiviral drugs have been approved for the prevention and treatment of YFV infections.
An overview on small molecules acting as broad-spectrum agents for yellow fever infection / Desantis, Jenny; Felicetti, Tommaso; Cannalire, Rolando. - In: EXPERT OPINION ON DRUG DISCOVERY. - ISSN 1746-045X. - 17:7(2022), pp. 755-773. [10.1080/17460441.2022.2084529]
An overview on small molecules acting as broad-spectrum agents for yellow fever infection
Cannalire, Rolando
2022
Abstract
Yellow fever virus (YFV) is a mosquito-borne flavivirus, endemic in 47 countries in Africa and South America, which causes febrile symptoms that can evolve in 15% of the patients to serious hemorrhagic conditions, liver injury, and multiorgan failure. Although a highly effective vaccine (YF-17D vaccine) is available, to date, no antiviral drugs have been approved for the prevention and treatment of YFV infections.| File | Dimensione | Formato | |
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