The clinico-pathological and molecular factors that drive the prognosis of invasive lobular breast carcinoma (ILC) are not entirely explored. In this regard, the development and validation of a prognostic model for ILC and the investigation of the distribution of molecular abnormalities (focusing on CDK4/6 alterations) according to prognosis were the aims of this study.
Targeted next-generation sequencing identifies genomic abnormalities potentially driving the prognosis of early-stage invasive lobular breast carcinoma patients stratified according to a validated clinico-pathological model / Carbognin, Luisa; Simbolo, Michele; Caliò, Anna; Vicentini, Caterina; Delfino, Pietro; Sperduti, Isabella; Fassan, Matteo; Schettini, Francesco; Dieci, Maria Vittoria; Griguolo, Gaia; Pilotto, Sara; Fiorio, Elena; Arpino, Grazia; Guarneri, Valentina; De Placido, Sabino; Conte, Pierfranco; Manfrin, Erminia; Brunelli, Matteo; Scambia, Giovanni; Scarpa, Aldo; Tortora, Giampaolo; Bria, Emilio. - In: BREAST. - ISSN 1532-3080. - 50:(2020), pp. 56-63. [10.1016/j.breast.2020.01.034]
Targeted next-generation sequencing identifies genomic abnormalities potentially driving the prognosis of early-stage invasive lobular breast carcinoma patients stratified according to a validated clinico-pathological model
Schettini, Francesco;Arpino, Grazia;De Placido, Sabino;Tortora, Giampaolo;
2020
Abstract
The clinico-pathological and molecular factors that drive the prognosis of invasive lobular breast carcinoma (ILC) are not entirely explored. In this regard, the development and validation of a prognostic model for ILC and the investigation of the distribution of molecular abnormalities (focusing on CDK4/6 alterations) according to prognosis were the aims of this study.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
