The natural tridecapeptide neurotensin has been emerged as a promising therapeutic scaffold for the treatment of neurological diseases and cancer. In this work, we aimed to identify the top 100 most cited original research papers as well as recent key studies related to neurotensins. The Web of Science Core Collection database was searched and the retrieved research articles were analyzed by using the VOSviewer software. The most cited original articles were published between 1973 and 2013. The top-cited article was by Carraway and Leeman reporting the discovery of neurotensin in 1973. The highly cited terms were associated with hypotension and angiotensin-converting-enzyme. The conducted analysis reveals the therapeutic potentials of neurotensin, and further impactful research toward its clinical development is warrantied.
Neurotensins and their therapeutic potential: research field study / Kan Yeung, Andy Wai; Georgieva, Maya G; Kirilov, Kiril; Balacheva, Aneliya A; Peeva, Martina I; Horbańczuk, Olaf K; Horbańczuk, Jarosław O; Lucarini, Massimo; Durazzo, Alessandra; Santini, Antonello; Souto, Eliana B; Pajpanova, Tamara I; Milella, Luigi; Atanasov, Atanas G; Tzvetkov, Nikolay T. - In: FUTURE MEDICINAL CHEMISTRY. - ISSN 1756-8919. - 12:19(2020), pp. 1779-1803. [10.4155/fmc-2020-0124]
Neurotensins and their therapeutic potential: research field study
Santini, Antonello;
2020
Abstract
The natural tridecapeptide neurotensin has been emerged as a promising therapeutic scaffold for the treatment of neurological diseases and cancer. In this work, we aimed to identify the top 100 most cited original research papers as well as recent key studies related to neurotensins. The Web of Science Core Collection database was searched and the retrieved research articles were analyzed by using the VOSviewer software. The most cited original articles were published between 1973 and 2013. The top-cited article was by Carraway and Leeman reporting the discovery of neurotensin in 1973. The highly cited terms were associated with hypotension and angiotensin-converting-enzyme. The conducted analysis reveals the therapeutic potentials of neurotensin, and further impactful research toward its clinical development is warrantied.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
