The management of patients with prostate cancer (PCa) and previous or synchronous colorectal cancer (CRC) represents a challenging issue. A systematic review was performed in May 2022 to summarize available evidence about the diagnosis, management, and outcomes of these patients. Twenty-seven studies involving 252 patients were identified. Overall, 163 (64.7%) and 89 (35.3%) patients had synchronous and metachronous PCa and CRC, respectively. In patients with synchronous diseases, PCa treatment involved active surveillance in 1 patient, radical prostatectomy (RP) in 36 patients, radiotherapy (RT) in 60 patients, RP plus RT in 1 patient, proton beam therapy in 1 patient, and cryoablation in 1 patient. In patients with previous CRC treatment, prostate biopsy was mostly performed by transrectal approach (n = 24). The trans-perineal and suprapubic approaches were adopted in 12 and 6 cases, respectively. Surgical PCa treatment in these cases involved endoscopic extraperitoneal RP, robot-assisted RP, and not otherwise specified RP in 30, 15, and 2 cases, respectively. Biochemical recurrence rates ranged from 20% to 28%. Non-surgical PCa treatment options included brachytherapy, RT plus androgen deprivation therapy, and RT alone in 23, 2 and 4 patients, respectively. PCa specific survival was reported by one study and was 100%.

Prostate Cancer Diagnosis, Treatment and Outcomes in Patients with Previous or Synchronous Colorectal Cancer: A Systematic Review of Published Evidence / Celentano, Giuseppe; Creta, Massimiliano; Napolitano, Luigi; Abate, Marco; La Rocca, Roberto; Capece, Marco; Mirone, Claudia; Morra, Simone; Di Bello, Francesco; Cirillo, Luigi; Mangiapia, Francesco; Califano, Gianluigi; Collà Ruvolo, Claudia; Sagnelli, Caterina; Sica, Antonello; Calogero, Armando; Iacono, Fabrizio; Fusco, Ferdinando; Mirone, Vincenzo; Longo, Nicola. - In: DIAGNOSTICS. - ISSN 2075-4418. - 12:6(2022), p. 1475. [10.3390/diagnostics12061475]

Prostate Cancer Diagnosis, Treatment and Outcomes in Patients with Previous or Synchronous Colorectal Cancer: A Systematic Review of Published Evidence

Celentano, Giuseppe;Creta, Massimiliano
Co-primo
;
Napolitano, Luigi;Abate, Marco;La Rocca, Roberto;Capece, Marco;Morra, Simone;Di Bello, Francesco;Cirillo, Luigi;Mangiapia, Francesco;Califano, Gianluigi;Collà Ruvolo, Claudia;Calogero, Armando;Iacono, Fabrizio;Mirone, Vincenzo;Longo, Nicola
2022

Abstract

The management of patients with prostate cancer (PCa) and previous or synchronous colorectal cancer (CRC) represents a challenging issue. A systematic review was performed in May 2022 to summarize available evidence about the diagnosis, management, and outcomes of these patients. Twenty-seven studies involving 252 patients were identified. Overall, 163 (64.7%) and 89 (35.3%) patients had synchronous and metachronous PCa and CRC, respectively. In patients with synchronous diseases, PCa treatment involved active surveillance in 1 patient, radical prostatectomy (RP) in 36 patients, radiotherapy (RT) in 60 patients, RP plus RT in 1 patient, proton beam therapy in 1 patient, and cryoablation in 1 patient. In patients with previous CRC treatment, prostate biopsy was mostly performed by transrectal approach (n = 24). The trans-perineal and suprapubic approaches were adopted in 12 and 6 cases, respectively. Surgical PCa treatment in these cases involved endoscopic extraperitoneal RP, robot-assisted RP, and not otherwise specified RP in 30, 15, and 2 cases, respectively. Biochemical recurrence rates ranged from 20% to 28%. Non-surgical PCa treatment options included brachytherapy, RT plus androgen deprivation therapy, and RT alone in 23, 2 and 4 patients, respectively. PCa specific survival was reported by one study and was 100%.
2022
Prostate Cancer Diagnosis, Treatment and Outcomes in Patients with Previous or Synchronous Colorectal Cancer: A Systematic Review of Published Evidence / Celentano, Giuseppe; Creta, Massimiliano; Napolitano, Luigi; Abate, Marco; La Rocca, Roberto; Capece, Marco; Mirone, Claudia; Morra, Simone; Di Bello, Francesco; Cirillo, Luigi; Mangiapia, Francesco; Califano, Gianluigi; Collà Ruvolo, Claudia; Sagnelli, Caterina; Sica, Antonello; Calogero, Armando; Iacono, Fabrizio; Fusco, Ferdinando; Mirone, Vincenzo; Longo, Nicola. - In: DIAGNOSTICS. - ISSN 2075-4418. - 12:6(2022), p. 1475. [10.3390/diagnostics12061475]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/888439
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