Spinal cord injury (SCI) is a relevant medical and social problem. According to the World Health Organization, the commonly estimated worldwide annual incidence of SCI is 40 to 80 cases per million population. After the SCI experience, most men present with sexual dysfunction (erectile dysfunction (ED) and ejaculatory dysfunction), fertility problems (such as impaired spermatogenesis, abnormalities in sperm viability, motility, and morphology), and systemic disorders such as genitourinary infection and endocrine imbalances. The best options available for managing the ejaculatory disorders in patients suffering from SCI are penile vibratory stimulation (PVS) and electroejaculation (EEJ). Furthermore, the treatment of ED in SCI patients consists of medical therapies including phosphodiesterase 5 inhibitors (PDE5i), intracavernosal injections (ICI), vacuum erection devices (VEDs), and surgical as penile prosthesis (PP). This review provides a snapshot of the current evidence for the mechanisms of sexual dysfunction and infertility in SCI patients, discusses the best management strategies for these conditions, and offers our perspective on the direction of future research.

Male Sexual Dysfunction and Infertility in Spinal Cord Injury Patients: State-of-the-Art and Future Perspectives / Di Bello, Francesco; Creta, Massimiliano; Napolitano, Luigi; Califano, Gianluigi; Passaro, Francesco; Morra, Simone; Giovanni, Angelo di; Fusco, Giovanni Maria; Cirillo, Luigi; Abate, Marco; Morgera, Vincenzo; Cacace, Gianluigi; De Luca, Luigi; Spena, Gianluca; Collà Ruvolo, Claudia; Calace, Francesco Paolo; Manfredi, Celeste; La Rocca, Roberto; Celentano, Giuseppe; Turco, Carmine; Capece, Marco; D’Alterio, Carlo; Giordano, Alessandro; Mauro, Ernesto di; Trama, Francesco; Amicuzi, Ugo; Arcaniolo, Davide; Fusco, Ferdinando; Longo, Nicola. - In: JOURNAL OF PERSONALIZED MEDICINE. - ISSN 2075-4426. - 12:6(2022), p. 873. [10.3390/jpm12060873]

Male Sexual Dysfunction and Infertility in Spinal Cord Injury Patients: State-of-the-Art and Future Perspectives

Di Bello, Francesco;Creta, Massimiliano
Co-primo
;
Napolitano, Luigi;Califano, Gianluigi;Passaro, Francesco;Morra, Simone;Giovanni, Angelo di;Fusco, Giovanni Maria;Cirillo, Luigi;Abate, Marco;Morgera, Vincenzo;Cacace, Gianluigi;De Luca, Luigi;Spena, Gianluca;Collà Ruvolo, Claudia;Calace, Francesco Paolo;Manfredi, Celeste;La Rocca, Roberto;Celentano, Giuseppe;Turco, Carmine;Capece, Marco;D’Alterio, Carlo;Giordano, Alessandro;Mauro, Ernesto di;Trama, Francesco;Amicuzi, Ugo;Arcaniolo, Davide;Longo, Nicola
2022

Abstract

Spinal cord injury (SCI) is a relevant medical and social problem. According to the World Health Organization, the commonly estimated worldwide annual incidence of SCI is 40 to 80 cases per million population. After the SCI experience, most men present with sexual dysfunction (erectile dysfunction (ED) and ejaculatory dysfunction), fertility problems (such as impaired spermatogenesis, abnormalities in sperm viability, motility, and morphology), and systemic disorders such as genitourinary infection and endocrine imbalances. The best options available for managing the ejaculatory disorders in patients suffering from SCI are penile vibratory stimulation (PVS) and electroejaculation (EEJ). Furthermore, the treatment of ED in SCI patients consists of medical therapies including phosphodiesterase 5 inhibitors (PDE5i), intracavernosal injections (ICI), vacuum erection devices (VEDs), and surgical as penile prosthesis (PP). This review provides a snapshot of the current evidence for the mechanisms of sexual dysfunction and infertility in SCI patients, discusses the best management strategies for these conditions, and offers our perspective on the direction of future research.
2022
Male Sexual Dysfunction and Infertility in Spinal Cord Injury Patients: State-of-the-Art and Future Perspectives / Di Bello, Francesco; Creta, Massimiliano; Napolitano, Luigi; Califano, Gianluigi; Passaro, Francesco; Morra, Simone; Giovanni, Angelo di; Fusco, Giovanni Maria; Cirillo, Luigi; Abate, Marco; Morgera, Vincenzo; Cacace, Gianluigi; De Luca, Luigi; Spena, Gianluca; Collà Ruvolo, Claudia; Calace, Francesco Paolo; Manfredi, Celeste; La Rocca, Roberto; Celentano, Giuseppe; Turco, Carmine; Capece, Marco; D’Alterio, Carlo; Giordano, Alessandro; Mauro, Ernesto di; Trama, Francesco; Amicuzi, Ugo; Arcaniolo, Davide; Fusco, Ferdinando; Longo, Nicola. - In: JOURNAL OF PERSONALIZED MEDICINE. - ISSN 2075-4426. - 12:6(2022), p. 873. [10.3390/jpm12060873]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/886811
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