Biogenetic proposals and biosynthetic studies on secondary metabolites of marine molluscs

Marine chemical diversity is generated by a large number of transformations often not noted in terrestrial counterparts. Life in the oceans differs in most respects from life on land and our knowledge of the genetics and biochemistry of marine organisms is still very limited to a small number of species. Biosynthetic studies and biogenetic speculations can therefore be crucial in predicting relevant enzymes and their encoding genes, with a view to setting the stage for rational engineering of marine natural products. A further useful outcome to the identification of biosynthetic pathways is the resulting classification of natural products, which can serve to correlate chemical diversity and biodiversity. This review summarizes the present knowledge on secondary metabolites biogenesis in marine opisthobranchs, a class of organisms that has been emerging as a prolific source of structurally diverse metabolites possessing a broad variety of biological activities.