Combined Effect of Mediterranean Diet and Aerobic Exercise on Weight Loss and Clinical Status in Obese Symptomatic Patients with Hypertrophic Cardiomyopathy

Limongelli, G.; Monda, E.; D'Aponte, A.; Caiazza, M.; Rubino, M.; Esposito, A.; Palmiero, G.; Moscarella, E.; Messina, G.; Calabro', P.; Scudiero, O.; Pacileo, G.; Monda, M.; Bossone, E.; Day, S. M.; Olivotto, I.

doi:10.1016/j.hfc.2021.01.003

We evaluated the impact of weight loss (WL) using a Mediterranean diet and mild-to-moderate–intensity aerobic exercise program, on clinical status of obese, symptomatic patients with hypertrophic cardiomyopathy (HCM). Compared with nonresponders, responders showed a significant reduction of left atrial diameter, left atrial volume index (LAVI), E/Eʹaverage, pulmonary artery systolic pressure (PASP), and a significant increase in VO2max (%) and peak workload. Body mass index changes correlated with reduction in left atrial diameter, LAVI, E/Eʹaverage, PASP, and increase of VO2max (mL/Kg/min), VO2max (%), peak workload. Mediterranean diet and aerobic exercise is associated with clinical-hemodynamic improvement in obese symptomatic HCM patients.

Combined Effect of Mediterranean Diet and Aerobic Exercise on Weight Loss and Clinical Status in Obese Symptomatic Patients with Hypertrophic Cardiomyopathy / Limongelli, G.; Monda, E.; D'Aponte, A.; Caiazza, M.; Rubino, M.; Esposito, A.; Palmiero, G.; Moscarella, E.; Messina, G.; Calabro', P.; Scudiero, O.; Pacileo, G.; Monda, M.; Bossone, E.; Day, S. M.; Olivotto, I.. - In: HEART FAILURE CLINICS. - ISSN 1551-7136. - 17:2(2021), pp. 303-313. [10.1016/j.hfc.2021.01.003]