Autophagy is a cellular self-degradative pathway. Our study unveiled a novel mechanism mediated by OFD1, the protein mutated in Oral-Facial-Digital type I syndrome, based on selective degradation of autophagic proteins, which enables cells to calibrate their self-degradation. We demonstrated that unrestrained autophagy contributes to renal cysts observed in Ofd1 mutants.

The role of OFD1 in selective autophagy / Franco, B.; Morleo, M.. - In: MOLECULAR & CELLULAR ONCOLOGY. - ISSN 2372-3556. - 8:3(2021), p. 1903291. [10.1080/23723556.2021.1903291]

The role of OFD1 in selective autophagy

Franco B.;
2021

Abstract

Autophagy is a cellular self-degradative pathway. Our study unveiled a novel mechanism mediated by OFD1, the protein mutated in Oral-Facial-Digital type I syndrome, based on selective degradation of autophagic proteins, which enables cells to calibrate their self-degradation. We demonstrated that unrestrained autophagy contributes to renal cysts observed in Ofd1 mutants.
2021
The role of OFD1 in selective autophagy / Franco, B.; Morleo, M.. - In: MOLECULAR & CELLULAR ONCOLOGY. - ISSN 2372-3556. - 8:3(2021), p. 1903291. [10.1080/23723556.2021.1903291]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/867651
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