Autophagy is a cellular self-degradative pathway. Our study unveiled a novel mechanism mediated by OFD1, the protein mutated in Oral-Facial-Digital type I syndrome, based on selective degradation of autophagic proteins, which enables cells to calibrate their self-degradation. We demonstrated that unrestrained autophagy contributes to renal cysts observed in Ofd1 mutants.
The role of OFD1 in selective autophagy / Franco, B.; Morleo, M.. - In: MOLECULAR & CELLULAR ONCOLOGY. - ISSN 2372-3556. - 8:3(2021), p. 1903291. [10.1080/23723556.2021.1903291]
The role of OFD1 in selective autophagy
Franco B.;
2021
Abstract
Autophagy is a cellular self-degradative pathway. Our study unveiled a novel mechanism mediated by OFD1, the protein mutated in Oral-Facial-Digital type I syndrome, based on selective degradation of autophagic proteins, which enables cells to calibrate their self-degradation. We demonstrated that unrestrained autophagy contributes to renal cysts observed in Ofd1 mutants.File in questo prodotto:
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