Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic output in contractile cells. Several studies have demonstrated that calcium (Ca2+) plays a pivotal role in this process. Here we present a comprehensive and updated description of the main systems involved in cardiac Ca2+ handling that ensure a functional EC coupling and their pathological alterations, mainly related to heart failure.
New insights in cardiac calcium handling and excitation-contraction coupling / Gambardella, J.; Trimarco, B.; Iaccarino, G.; Santulli, G.. - 1067:(2018), pp. 373-385. [10.1007/5584_2017_106]
New insights in cardiac calcium handling and excitation-contraction coupling
Gambardella J.;Trimarco B.;Iaccarino G.;Santulli G.
2018
Abstract
Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic output in contractile cells. Several studies have demonstrated that calcium (Ca2+) plays a pivotal role in this process. Here we present a comprehensive and updated description of the main systems involved in cardiac Ca2+ handling that ensure a functional EC coupling and their pathological alterations, mainly related to heart failure.File in questo prodotto:
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