The gut-brain axis (GBA) is a complex communication network interfacing the gut and the brain of a single individual. The central (CNS) and enteric (ENS) nervous systems are, of course, communicating; however, other pathways are involved in GBA, among which are immune activation, intestinal barrier function, and enteroendocrine signaling. All these communication lines are bidirectional and involve neuro-immuno-endocrine mediators. The reason for the development of such a complex network is to maintain gastrointestinal homeostasis keeping in mind its links with cognitive and affective functions. Recently, the role of enteric flora, or microbiota, has been recognized as a part of the gut-brain axis. The gut microbiota can modulate brain function, forming a crucial link in the bidirectional interactions between the intestine and the nervous system.
Gut-brain axis: A new revolution to understand the pathogenesis of autism and other severe neurological diseases / de Magistris, L.; Siniscalco, D.; Bravaccio, C.; Loguercio, C.. - (2016), pp. 49-65. [10.1007/978-3-319-30361-1_4]
Gut-brain axis: A new revolution to understand the pathogenesis of autism and other severe neurological diseases
Bravaccio C.;
2016
Abstract
The gut-brain axis (GBA) is a complex communication network interfacing the gut and the brain of a single individual. The central (CNS) and enteric (ENS) nervous systems are, of course, communicating; however, other pathways are involved in GBA, among which are immune activation, intestinal barrier function, and enteroendocrine signaling. All these communication lines are bidirectional and involve neuro-immuno-endocrine mediators. The reason for the development of such a complex network is to maintain gastrointestinal homeostasis keeping in mind its links with cognitive and affective functions. Recently, the role of enteric flora, or microbiota, has been recognized as a part of the gut-brain axis. The gut microbiota can modulate brain function, forming a crucial link in the bidirectional interactions between the intestine and the nervous system.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.