Harzianic acid is a secondary metabolite of Trichoderma, structurally belonging to the dienyltetramic acid subgroup of the tetramic acids. Biological activities of harzianic acid are of great interest for its antimicrobial and plant growth-promoting activities, which might be related to its chelating properties. In the present work harzianic acid, isolated from cultures of a strain of Trichoderma pleuroticola associated to the gastropod Melarhaphe neritoides, was studied as a complexant agent of a number of biologically relevant transition metals (i.e., Zn2+, Fe2+, Cu2+, and Mn2+), using UV-VIS, potentiometry, MS and NMR techniques. Our findings show the coordination capacity of harzianic acid toward the above cations through the formation of neutral or charged complexes in a variable ratio depending on the metal and pH conditions.
Bivalent metal-chelating properties of harzianic acid produced by Trichoderma pleuroticola associated to the gastropod Melarhaphe neritoides / De Tommaso, G., Salvatore, M.M., Nicoletti, R., Della Greca, M., Vinale, F., Bottiglieri, A., Staropoli, A., Salvatore, F., Lorito, M., Iuliano, M., Andolfi, A.. - In: MOLECULES. - ISSN 1420-3049. - 25:9(2020), pp. 2147-N/A. [10.3390/molecules25092147]
Bivalent metal-chelating properties of harzianic acid produced by Trichoderma pleuroticola associated to the gastropod Melarhaphe neritoides
De Tommaso G.Writing – Original Draft Preparation
;Salvatore M. M.Investigation
;Nicoletti R.Membro del Collaboration Group
;Della Greca M.Formal Analysis
;Vinale F.Data Curation
;Bottiglieri A.Formal Analysis
;Staropoli A.Investigation
;Salvatore F.Data Curation
;Lorito M.Visualization
;Iuliano M.
Data Curation
;Andolfi A.
Writing – Review & Editing
2020
Abstract
Harzianic acid is a secondary metabolite of Trichoderma, structurally belonging to the dienyltetramic acid subgroup of the tetramic acids. Biological activities of harzianic acid are of great interest for its antimicrobial and plant growth-promoting activities, which might be related to its chelating properties. In the present work harzianic acid, isolated from cultures of a strain of Trichoderma pleuroticola associated to the gastropod Melarhaphe neritoides, was studied as a complexant agent of a number of biologically relevant transition metals (i.e., Zn2+, Fe2+, Cu2+, and Mn2+), using UV-VIS, potentiometry, MS and NMR techniques. Our findings show the coordination capacity of harzianic acid toward the above cations through the formation of neutral or charged complexes in a variable ratio depending on the metal and pH conditions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
