Heterocyclic compounds used in the treatment of kinetoplastid infection and their preparation

The invention relates to compds. of formula I, pharmaceutical compns. comprising these compds., their use in the treatment of kinetoplastid infections and their prepn. Compds. of formula I, wherein A is absent, O, S, etc.; B is absent, (CH2)​n and CO; Z is absent, CO, SO2, etc.; X and Y are independently H, halo, C1-​6 alkyl, etc.; m and n are 1 or 2 wherein at least one must be 1; p is 0 , 1 and 2; Het is 1H-​imidazole, 4H-​1,​2,​4-​triazole, oxazole, etc.; R1 is naphthalen-​2-​yl, 2-​methoxyquinolin-​3-​yl, pryimdin-​5-​yl, etc.; R2 is H, C6-​10 aryl, C3-​15 heterocyclyl, etc.; and pharmaceutically acceptable salts, tautomers and stereoisomers thereof, are claimed. Compd. II.bul.TFA was prepd. using a multistep procedure (procedure given)​. Compds. of the invention were tested for their inhibitory activity against T. brucei (data given)​.