Considering aryl azides as electrophilic partners for the TosMIC mediated Van Leusen reaction, a novel multicomponent synthesis of 4-tosyl-1-arylimidazoles is reported. In this transformation, two molecules of TosMIC participate in the reaction mechanism in two different ways, with the second molecule undergoing a novel type of fragmentation resulting in the incorporation of a C-H into the final product.

Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles / Necardo, C.; Alfano, A. I.; Del Grosso, E.; Pelliccia, S.; Galli, U.; Novellino, E.; Meneghetti, F.; Giustiniano, M.; Tron, G. C.. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 84:24(2019), pp. 16299-16307. [10.1021/acs.joc.9b02546]

Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles

Alfano A. I.;Pelliccia S.;Novellino E.;Giustiniano M.
;
2019

Abstract

Considering aryl azides as electrophilic partners for the TosMIC mediated Van Leusen reaction, a novel multicomponent synthesis of 4-tosyl-1-arylimidazoles is reported. In this transformation, two molecules of TosMIC participate in the reaction mechanism in two different ways, with the second molecule undergoing a novel type of fragmentation resulting in the incorporation of a C-H into the final product.
2019
Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles / Necardo, C.; Alfano, A. I.; Del Grosso, E.; Pelliccia, S.; Galli, U.; Novellino, E.; Meneghetti, F.; Giustiniano, M.; Tron, G. C.. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 84:24(2019), pp. 16299-16307. [10.1021/acs.joc.9b02546]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/826120
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