Background:: The relationship between exclusive enteral nutrition (EEN) and bone status is poorly defined in pediatric Crohn disease (CD). Aims:: The aim of this study was to investigate the impact of EEN on body composition, nutritional status, and bone mineral density (BMD) in an incident CD cohort. Methods:: 18 newly diagnosed CD children starting EEN for 8 weeks were prospectively enrolled and evaluated at baseline and after 8 (T8), 26 (T26) and 52 weeks (T52) from diagnosis. The Fat Free Mass (FFM) and the Resting Energy Expenditure (REE) were measured through Bioelectrical Impedance (BIA) and the BMD was assessed by dual-energy X-ray (DXA). We compared DXA data of IBD patients to the data obtained in 15 healthy controls. Results:: CD children had a significant lower BMD compared to healthy control both at baseline (p<0.0001), and after EEN therapy at T52 (p=0.0004); although at this latest time point CD children had a significant increase of BMD compared to baseline (p=0.0015). The BIA analysis showed a significant increase at T26 and T52 of FFM and REE. T52. FFM measured by BIA and BMD measured by DXA were significantly correlated. Conclusion:: EEN improves nutritional status and bone mineral composition.
Improvement of body composition and bone mineral density after enteral nutrition in pediatric Crohn disease / Strisciuglio, C.; Scarpato, E.; Cenni, S.; Serra, M. R.; Giugliano, F. P.; Mainolfi, C. G.; Dolce, P.; Martinelli, M.; Staiano, A.; Miele, E.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 52:6(2020), pp. 630-636. [10.1016/j.dld.2020.03.004]
Improvement of body composition and bone mineral density after enteral nutrition in pediatric Crohn disease
Strisciuglio C.;Scarpato E.;Cenni S.;Serra M. R.;Giugliano F. P.;Mainolfi C. G.;Dolce P.;Martinelli M.;Staiano A.;Miele E.
2020
Abstract
Background:: The relationship between exclusive enteral nutrition (EEN) and bone status is poorly defined in pediatric Crohn disease (CD). Aims:: The aim of this study was to investigate the impact of EEN on body composition, nutritional status, and bone mineral density (BMD) in an incident CD cohort. Methods:: 18 newly diagnosed CD children starting EEN for 8 weeks were prospectively enrolled and evaluated at baseline and after 8 (T8), 26 (T26) and 52 weeks (T52) from diagnosis. The Fat Free Mass (FFM) and the Resting Energy Expenditure (REE) were measured through Bioelectrical Impedance (BIA) and the BMD was assessed by dual-energy X-ray (DXA). We compared DXA data of IBD patients to the data obtained in 15 healthy controls. Results:: CD children had a significant lower BMD compared to healthy control both at baseline (p<0.0001), and after EEN therapy at T52 (p=0.0004); although at this latest time point CD children had a significant increase of BMD compared to baseline (p=0.0015). The BIA analysis showed a significant increase at T26 and T52 of FFM and REE. T52. FFM measured by BIA and BMD measured by DXA were significantly correlated. Conclusion:: EEN improves nutritional status and bone mineral composition.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
