Ungeremine (UNG) is an alkaloid typically isolated from Pancratium maritimum or synthesized by the oxidation of lycorine. This antifungal alkaloid was incorporated into electrospun nanofibers based on blends of poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG). The effect of the UNG on the structure, morphology, and thermal properties of the fibers was evaluated, and the release of the alkaloid from the fibers was quantified. Studies on the release of the UNG for the nanofibers show that the release rate is related to the amount and distribution of the PEG in the nanofiber matrix. Initial burst release of the antifungal alkaloid is related to the PEG in the nanofibers, where after a sustained release occurs indicating that the UNG is present in both the PLA and PEG domains in the nanofibers.
The incorporation and release of ungeremine, an antifungal Amaryllidaceae alkaloid, in poly(lactic acid)/poly(ethylene glycol) nanofibers / Moeini, A.; Cimmino, A.; Masi, M.; Evidente, A.; Van Reenen, A.. - In: JOURNAL OF APPLIED POLYMER SCIENCE. - ISSN 0021-8995. - (2020), p. 49098. [10.1002/app.49098]
The incorporation and release of ungeremine, an antifungal Amaryllidaceae alkaloid, in poly(lactic acid)/poly(ethylene glycol) nanofibers
Moeini A.Conceptualization
;Cimmino A.Writing – Review & Editing
;Masi M.Investigation
;Evidente A.Supervision
;
2020
Abstract
Ungeremine (UNG) is an alkaloid typically isolated from Pancratium maritimum or synthesized by the oxidation of lycorine. This antifungal alkaloid was incorporated into electrospun nanofibers based on blends of poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG). The effect of the UNG on the structure, morphology, and thermal properties of the fibers was evaluated, and the release of the alkaloid from the fibers was quantified. Studies on the release of the UNG for the nanofibers show that the release rate is related to the amount and distribution of the PEG in the nanofiber matrix. Initial burst release of the antifungal alkaloid is related to the PEG in the nanofibers, where after a sustained release occurs indicating that the UNG is present in both the PLA and PEG domains in the nanofibers.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
