Iminosugars represent the most promising class of therapeutically useful glycomimetics. Because of their ability to mimic structure and properties of natural monosaccharides, iminosugars are able to interfere with disease-related carbohydrate-processing enzymes. Despite their great therapeutic potential, iminosugars suffer of poor selectivity, thereby leading to the onset of undesired side effects after prolonged administration. In this area, a valid alternative is offered by L-iminosugars. The last ones are non-superimposable mirror images of natural iminosugars; studies have demonstrated that they act as either inhibitors or chaperones of various glycosidases, although working in a more markedly selective manner
Synthesis of N-Alkylated L-Iminosugars and their Therapeutic Application in Cystic Fibrosis Lung Disease / D'Alonzo, Daniele.; De Fenza, Maria.; Esposito, Anna.; Munari, S.; Loberto, N.; Santangelo, A.; Lampronti, I.; Tamanini, A.; Rossi, A.; Ranucci, S.; De Fino, I.; Bragonzi, A.; Aureli, M.; Sonnino, A.; Lippi, G.; Gambari, R.; Cabrini, G.; Dechecchi, M. C.; Guaragna, A.. - (2018). (Intervento presentato al convegno Spanish-Italian Symposium on Organic Chemistry-SISOCXII tenutosi a Ferrara, Italia nel 2-4 Luglio 2018).
Synthesis of N-Alkylated L-Iminosugars and their Therapeutic Application in Cystic Fibrosis Lung Disease
D'Alonzo, Daniele.;De Fenza, Maria.;Esposito, Anna.;Guaragna, A.
2018
Abstract
Iminosugars represent the most promising class of therapeutically useful glycomimetics. Because of their ability to mimic structure and properties of natural monosaccharides, iminosugars are able to interfere with disease-related carbohydrate-processing enzymes. Despite their great therapeutic potential, iminosugars suffer of poor selectivity, thereby leading to the onset of undesired side effects after prolonged administration. In this area, a valid alternative is offered by L-iminosugars. The last ones are non-superimposable mirror images of natural iminosugars; studies have demonstrated that they act as either inhibitors or chaperones of various glycosidases, although working in a more markedly selective mannerI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.