Learning from the lesson of anti-HHV hexitol nucleosides, compounds 1-4 are conceived as conformational preorganized nucleosides, exploiting the rigidity of the piperidinyl core to improve inhibition potency and selectivity. Access to nucleosides 1-4 has been devised starting from the well-known glucosidase inhibitor 1-deoxynojirimycin (DNJ), (3) efficiently prepared with a general and highly selective procedure by a de novo synthetic approach.

Synthesis and Biological Evaluation of Novel Piperidinyl Iminosugar-Based Nucleoside / DE FENZA, Maria; Esposito, Anna; Andrei, Graciela; Snoeck, Robert; Guaragna, Annalisa; D'Alonzo, Daniele. - (2017). (Intervento presentato al convegno XXVI Congresso Nazionale della Società Chimica Italiana tenutosi a Paestum (SA), Italia nel 10-14 settembre 2017).

Synthesis and Biological Evaluation of Novel Piperidinyl Iminosugar-Based Nucleoside

Maria De Fenza;Anna Esposito;Annalisa Guaragna;Daniele D’Alonzo
2017

Abstract

Learning from the lesson of anti-HHV hexitol nucleosides, compounds 1-4 are conceived as conformational preorganized nucleosides, exploiting the rigidity of the piperidinyl core to improve inhibition potency and selectivity. Access to nucleosides 1-4 has been devised starting from the well-known glucosidase inhibitor 1-deoxynojirimycin (DNJ), (3) efficiently prepared with a general and highly selective procedure by a de novo synthetic approach.
2017
Synthesis and Biological Evaluation of Novel Piperidinyl Iminosugar-Based Nucleoside / DE FENZA, Maria; Esposito, Anna; Andrei, Graciela; Snoeck, Robert; Guaragna, Annalisa; D'Alonzo, Daniele. - (2017). (Intervento presentato al convegno XXVI Congresso Nazionale della Società Chimica Italiana tenutosi a Paestum (SA), Italia nel 10-14 settembre 2017).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/772548
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