Histone deacetylases (HDACs) regulate the expression and activity of numerous proteins involved in the initiation and progression of cancer. Currently, three hydroxamate-containing HDAC pan-inhibitors have been approved as antitumor agents.
Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies / Brindisi, M., Cavella, C., Brogi, S., Nebbioso, A., Senger, J., Maramai, S., Ciotta, A., Iside, C., Butini, S., Lamponi, S., Novellino, E., Altucci, L., Jung, M., Campiani, G., Gemma, S.. - In: FUTURE MEDICINAL CHEMISTRY. - ISSN 1756-8919. - 8:13(2016), pp. 1573-1587. [10.4155/fmc-2016-0068]
Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies
Brindisi MargheritaPrimo
;Novellino Ettore;
2016
Abstract
Histone deacetylases (HDACs) regulate the expression and activity of numerous proteins involved in the initiation and progression of cancer. Currently, three hydroxamate-containing HDAC pan-inhibitors have been approved as antitumor agents.File in questo prodotto:
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