Histone deacetylases (HDACs) regulate the expression and activity of numerous proteins involved in the initiation and progression of cancer. Currently, three hydroxamate-containing HDAC pan-inhibitors have been approved as antitumor agents.
Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies / Brindisi, Margherita; Cavella, Caterina; Brogi, Simone; Nebbioso, Angela; Senger, Johanna; Maramai, Samuele; Ciotta, Alfonso; Iside, Concetta; Butini, Stefania; Lamponi, Stefania; Novellino, Ettore; Altucci, Lucia; Jung, Manfred; Campiani, Giuseppe; Gemma, Sandra. - In: FUTURE MEDICINAL CHEMISTRY. - ISSN 1756-8919. - 8:13(2016), pp. 1573-1587. [10.4155/fmc-2016-0068]
Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies
Brindisi MargheritaPrimo
;Novellino Ettore;
2016
Abstract
Histone deacetylases (HDACs) regulate the expression and activity of numerous proteins involved in the initiation and progression of cancer. Currently, three hydroxamate-containing HDAC pan-inhibitors have been approved as antitumor agents.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
