In search for novel drug targets aimed to control CF lung infections, a key role of the non-lysosomal glucosidase 2 (GBA2-encoded GNLase) in proinflammatory state characterizing CF cells has been highlighted. As matter of fact, Miglustat® (d-NBDNJ) has been found to reduce the inflammatory response in P. aeruginosa infected CF bronchial cells showing a therapeutic potential of iminosugars in CF lung disease treatment. However, pharmacological use of d-iminosugars is hampered by their poor in vivo selectivity. Conversely, their non-superimposable mirror image, L-iminosugars have shown higher selectivity acting as inhibitors or enhancers of glycosidases and glycosyltransferases

N-Alkylated L-Iminosugars as novel anti-inflammatory and anti-biofilm tools for Cystic Fibrosis Lung Infections

Esposito Anna;De Fenza Maria;D’Alonzo Daniele;De Gregorio Eliana;Guaragna, A
2019

Abstract

In search for novel drug targets aimed to control CF lung infections, a key role of the non-lysosomal glucosidase 2 (GBA2-encoded GNLase) in proinflammatory state characterizing CF cells has been highlighted. As matter of fact, Miglustat® (d-NBDNJ) has been found to reduce the inflammatory response in P. aeruginosa infected CF bronchial cells showing a therapeutic potential of iminosugars in CF lung disease treatment. However, pharmacological use of d-iminosugars is hampered by their poor in vivo selectivity. Conversely, their non-superimposable mirror image, L-iminosugars have shown higher selectivity acting as inhibitors or enhancers of glycosidases and glycosyltransferases
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/770920
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