Glycosidase inhibition is expected to be addressed toward specific non-enantioselective, lipophilic enzymes, such as glucocerebrosidases GBA1 and GBA2. In order to assess the effect of chirality and lipophilicity of alkylated iminosugars on the activity/selectivity of such enzymes, some D and L-alkylated iminosugars as 1 and ent-1, in particular those having a gluco-configured pseudo-saccharide moiety (DNJ derivatives) have been synthesized

Evaluation of anti-inflammatory treatments for CF lung disease in murine models of lung infection in vivo / Dechecchi, M. C.; Olioso, D.; Santangelo, A.; Tamanini, A.; Cabrini, G.; Guaragna, A.; D’Alonzo, Daniele.; De Fenza, Maria.; Esposito, Anna.. - (2018). (Intervento presentato al convegno XVI Convention d’Autunno dei ricercatori in Fibrosi Cistica tenutosi a Verona, Italy nel 22-24 Novembre 2018).

Evaluation of anti-inflammatory treatments for CF lung disease in murine models of lung infection in vivo

Guaragna A.;D’Alonzo Daniele.;De Fenza Maria.;Esposito Anna.
2018

Abstract

Glycosidase inhibition is expected to be addressed toward specific non-enantioselective, lipophilic enzymes, such as glucocerebrosidases GBA1 and GBA2. In order to assess the effect of chirality and lipophilicity of alkylated iminosugars on the activity/selectivity of such enzymes, some D and L-alkylated iminosugars as 1 and ent-1, in particular those having a gluco-configured pseudo-saccharide moiety (DNJ derivatives) have been synthesized
2018
Evaluation of anti-inflammatory treatments for CF lung disease in murine models of lung infection in vivo / Dechecchi, M. C.; Olioso, D.; Santangelo, A.; Tamanini, A.; Cabrini, G.; Guaragna, A.; D’Alonzo, Daniele.; De Fenza, Maria.; Esposito, Anna.. - (2018). (Intervento presentato al convegno XVI Convention d’Autunno dei ricercatori in Fibrosi Cistica tenutosi a Verona, Italy nel 22-24 Novembre 2018).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/770906
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