Gliomas aberrantly express programmed cell death ligand-1 (PD-L1), which has a pivotal role in immunoevasion. The splicing isoform of FKBP5, termed FKBP51s, is a PD-L1 foldase, assisting the immune checkpoint molecule in maturation and expression on the plasma membrane. The concept that PD-L1 supports tumor-intrinsic properties is increasingly emerging. Our findings confirm the pro-tumoral effect of PD-L1 on human glioma cell survival, stemness capacity and resistance, and show how, by targeting FKBP51s PD-L1 and its pro-tumoral properties could be hampered, thereby affecting the self-renewal and growth capacities of glioblastoma cells in vitro and in vivo.

Programmed death ligand 1 (PD-L1) sustains glioblastoma stemness and tumorigenic potential / Romano, Simona. - (2019). (Intervento presentato al convegno WCCBI 2019, 3rd World Congress on Cancer Biology and Immunology tenutosi a Milan, Italy nel March 11-12, 2019).

Programmed death ligand 1 (PD-L1) sustains glioblastoma stemness and tumorigenic potential

ROMANO SIMONA
2019

Abstract

Gliomas aberrantly express programmed cell death ligand-1 (PD-L1), which has a pivotal role in immunoevasion. The splicing isoform of FKBP5, termed FKBP51s, is a PD-L1 foldase, assisting the immune checkpoint molecule in maturation and expression on the plasma membrane. The concept that PD-L1 supports tumor-intrinsic properties is increasingly emerging. Our findings confirm the pro-tumoral effect of PD-L1 on human glioma cell survival, stemness capacity and resistance, and show how, by targeting FKBP51s PD-L1 and its pro-tumoral properties could be hampered, thereby affecting the self-renewal and growth capacities of glioblastoma cells in vitro and in vivo.
2019
Programmed death ligand 1 (PD-L1) sustains glioblastoma stemness and tumorigenic potential / Romano, Simona. - (2019). (Intervento presentato al convegno WCCBI 2019, 3rd World Congress on Cancer Biology and Immunology tenutosi a Milan, Italy nel March 11-12, 2019).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/765904
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