Some experimental trials have demonstrated that rapamycin (RAPA) is able to inhibit HIV-1 progression in three different ways: (1) reducing CCR5-gene transcription, (2) blocking interleukin-2 intracellular secondary messenger (mammalian target of rapamycin), and (3) up-regulating the beta-chemokine macrophage inflammatory protein (MIP; MIP-1alpha and MIP-1beta). We present the preliminary results of a prospective nonrandomized trial concerning the first HIV patient series receiving RAPA monotherapy after liver transplantation (LT).

First report on a series of HIV patients undergoing rapamycin monotherapy after liver transplantation / Di Benedetto, Fabrizio; Di Sandro, Stefano; De Ruvo, Nicola; Montalti, Roberto; Ballarin, Roberto; Guerrini, Gian Piero; Spaggiari, Mario; Guaraldi, Giovanni; Gerunda, Giorgio. - In: TRANSPLANTATION. - ISSN 1534-6080. - 89:6(2010), p. 733-8. [10.1097/TP.0b013e3181c7dcc0]

First report on a series of HIV patients undergoing rapamycin monotherapy after liver transplantation

Montalti, Roberto;
2010

Abstract

Some experimental trials have demonstrated that rapamycin (RAPA) is able to inhibit HIV-1 progression in three different ways: (1) reducing CCR5-gene transcription, (2) blocking interleukin-2 intracellular secondary messenger (mammalian target of rapamycin), and (3) up-regulating the beta-chemokine macrophage inflammatory protein (MIP; MIP-1alpha and MIP-1beta). We present the preliminary results of a prospective nonrandomized trial concerning the first HIV patient series receiving RAPA monotherapy after liver transplantation (LT).
2010
First report on a series of HIV patients undergoing rapamycin monotherapy after liver transplantation / Di Benedetto, Fabrizio; Di Sandro, Stefano; De Ruvo, Nicola; Montalti, Roberto; Ballarin, Roberto; Guerrini, Gian Piero; Spaggiari, Mario; Guaraldi, Giovanni; Gerunda, Giorgio. - In: TRANSPLANTATION. - ISSN 1534-6080. - 89:6(2010), p. 733-8. [10.1097/TP.0b013e3181c7dcc0]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/759358
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