Since 1999, a new immunosuppressive drug was administered to renal transplant patients. The SRL molecule acts by blocking post-receptor signal transduction of interleukin-2 (IL-2) interacting with a family of intracellular binding proteins termed immunophilins FKBPs. Among these FKBPs, FK506 12-kd binding protein is the most relevant. SRL is an immunosuppressive drug. Therefore it can inhibit the immune system; at the same time the drug is not nephrotoxic, neurotoxic, and without diabetogenic effects.

Sirolimus monotherapy in liver transplantation / Di Benedetto, F., Di Sandro, S., De Ruvo, N., Masetti, M., Montalti, R., Romano, A., Guerrini, G.P., Ballarin, R., DE BLASIIS, M.R., Gerunda, G.E.. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 39:6(2007), p. 1930-2. [10.1016/j.transproceed.2007.07.018]

Sirolimus monotherapy in liver transplantation

Montalti, R;DE BLASIIS, MARIA ROBERTA;
2007

Abstract

Since 1999, a new immunosuppressive drug was administered to renal transplant patients. The SRL molecule acts by blocking post-receptor signal transduction of interleukin-2 (IL-2) interacting with a family of intracellular binding proteins termed immunophilins FKBPs. Among these FKBPs, FK506 12-kd binding protein is the most relevant. SRL is an immunosuppressive drug. Therefore it can inhibit the immune system; at the same time the drug is not nephrotoxic, neurotoxic, and without diabetogenic effects.
2007
Sirolimus monotherapy in liver transplantation / Di Benedetto, F., Di Sandro, S., De Ruvo, N., Masetti, M., Montalti, R., Romano, A., Guerrini, G.P., Ballarin, R., DE BLASIIS, M.R., Gerunda, G.E.. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 39:6(2007), p. 1930-2. [10.1016/j.transproceed.2007.07.018]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/759354
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 18
social impact