Since 1999, a new immunosuppressive drug was administered to renal transplant patients. The SRL molecule acts by blocking post-receptor signal transduction of interleukin-2 (IL-2) interacting with a family of intracellular binding proteins termed immunophilins FKBPs. Among these FKBPs, FK506 12-kd binding protein is the most relevant. SRL is an immunosuppressive drug. Therefore it can inhibit the immune system; at the same time the drug is not nephrotoxic, neurotoxic, and without diabetogenic effects.

Sirolimus monotherapy in liver transplantation / Di Benedetto, F; Di Sandro, S; De Ruvo, N; Masetti, M; Montalti, R; Romano, A; Guerrini, G P; Ballarin, R; DE BLASIIS, MARIA ROBERTA; Gerunda, G E. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 39:6(2007), p. 1930-2. [10.1016/j.transproceed.2007.07.018]

Sirolimus monotherapy in liver transplantation

Montalti, R;DE BLASIIS, MARIA ROBERTA;
2007

Abstract

Since 1999, a new immunosuppressive drug was administered to renal transplant patients. The SRL molecule acts by blocking post-receptor signal transduction of interleukin-2 (IL-2) interacting with a family of intracellular binding proteins termed immunophilins FKBPs. Among these FKBPs, FK506 12-kd binding protein is the most relevant. SRL is an immunosuppressive drug. Therefore it can inhibit the immune system; at the same time the drug is not nephrotoxic, neurotoxic, and without diabetogenic effects.
2007
Sirolimus monotherapy in liver transplantation / Di Benedetto, F; Di Sandro, S; De Ruvo, N; Masetti, M; Montalti, R; Romano, A; Guerrini, G P; Ballarin, R; DE BLASIIS, MARIA ROBERTA; Gerunda, G E. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 39:6(2007), p. 1930-2. [10.1016/j.transproceed.2007.07.018]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/759354
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