Sulfated glycosaminoglycans (heparan sulfate, chondroitin sulfate, dermatan sulfate, and keratan sulfate) are a family of complex polysaccharides ubiquitously, but not exclusively, distributed among mammals, found both in extracellular matrices and on cell surfaces. They play key roles in a myriad of physiological and pathological processes, including, among others, angiogenesis, cancer, immunity, and infectious diseases. Here the main issues concerning their chemical structure, biosynthesis, extraction, and purification from natural sources, structural characterization, as well as their most important biological functions are discussed.
Chondroitin, Dermatan, Heparan, and Keratan Sulfate: Structure and Functions / Bedini, Emiliano; Corsaro, MARIA MICHELA; Fernández-Mayoralas, Alfonso; Iadonisi, Alfonso. - 12:(2019), pp. 187-233. [10.1007/978-3-030-12919-4_5]
Chondroitin, Dermatan, Heparan, and Keratan Sulfate: Structure and Functions
Emiliano Bedini
;Maria Michela Corsaro;Alfonso Iadonisi
2019
Abstract
Sulfated glycosaminoglycans (heparan sulfate, chondroitin sulfate, dermatan sulfate, and keratan sulfate) are a family of complex polysaccharides ubiquitously, but not exclusively, distributed among mammals, found both in extracellular matrices and on cell surfaces. They play key roles in a myriad of physiological and pathological processes, including, among others, angiogenesis, cancer, immunity, and infectious diseases. Here the main issues concerning their chemical structure, biosynthesis, extraction, and purification from natural sources, structural characterization, as well as their most important biological functions are discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
