Infections caused by human cytomegalovirus are important causes of fetal and neonatal morbidity and mortality. Ganciclovir ([(9-(1,3-dihydroxy-2- propoxymethyl) guanine, GCV) is a synthetic acyclic nucleoside which has shown activity against Cytomegalovirus. GCV treatment has been associated with serious toxic hematological effects such as neutropenia and leukopenia, thus drug monitoring is needed, especially in the case of newborns. The aim of the work is to develop and validate an HPLC method for the quantification of GCV in plasma
Determination of Ganciclovir in Plasma of Newborns with Congenital CMV Infection / Laneri, S.; Padula, C.; Buffolano, W.; Santi, P.; Dini, I.. - In: BIOMEDICAL JOURNAL OF SCIENTIFIC & TECHNICAL RESEARCH. - ISSN 2574-1241. - 18:2(2019), pp. 13408-13411. [10.26717.2019/18.003122]
Determination of Ganciclovir in Plasma of Newborns with Congenital CMV Infection
LANERI S.Project Administration
;BUFFOLANO W.Formal Analysis
;DINI I.
Writing – Original Draft Preparation
2019
Abstract
Infections caused by human cytomegalovirus are important causes of fetal and neonatal morbidity and mortality. Ganciclovir ([(9-(1,3-dihydroxy-2- propoxymethyl) guanine, GCV) is a synthetic acyclic nucleoside which has shown activity against Cytomegalovirus. GCV treatment has been associated with serious toxic hematological effects such as neutropenia and leukopenia, thus drug monitoring is needed, especially in the case of newborns. The aim of the work is to develop and validate an HPLC method for the quantification of GCV in plasma| File | Dimensione | Formato | |
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