The n-butanolic extract, from an Iranian specimen of Nepeta asterotricha Rech. f. (NABE), displayed anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated J774A.1 macrophages, which reduced nitrites and cytokines production. Bioassay guided fractionation of the extract led to the isolation of four iridoid glycosides, including a new one known as nepetamoside (1), one hexenyl-diglycoside, and some polyphenol and flavonoid components. None of the isolated iridoid components displayed significant effects on nitrites formation in an in vitro LPS-induced model of inflammation, thus suggesting that the plant anti-inflammatory effect is probably due to a synergistic action among its constituents

Phytochemical and biological studies of Nepeta asterotricha Rech. f. (Lamiaceae): Isolation of Nepetamoside / Mostafa Goldansaz, Seyed; Festa, Carmen; Pagano, Ester; DE MARINO, Simona; Finamore, Claudia; Parisi, OLGA ALESSANDRA; Borrelli, Francesca; Sonboli, Ali; D'Auria, MARIA VALERIA. - In: MOLECULES. - ISSN 1420-3049. - 24:9(2019), pp. 1684-1695. [10.3390/molecules24091684]

Phytochemical and biological studies of Nepeta asterotricha Rech. f. (Lamiaceae): Isolation of Nepetamoside

Carmen Festa
Secondo
;
Ester Pagano;Simona De Marino;Claudia Finamore;Olga Alessandra Parisi;Francesca Borrelli;Maria Valeria D’Auria
Ultimo
2019

Abstract

The n-butanolic extract, from an Iranian specimen of Nepeta asterotricha Rech. f. (NABE), displayed anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated J774A.1 macrophages, which reduced nitrites and cytokines production. Bioassay guided fractionation of the extract led to the isolation of four iridoid glycosides, including a new one known as nepetamoside (1), one hexenyl-diglycoside, and some polyphenol and flavonoid components. None of the isolated iridoid components displayed significant effects on nitrites formation in an in vitro LPS-induced model of inflammation, thus suggesting that the plant anti-inflammatory effect is probably due to a synergistic action among its constituents
2019
Phytochemical and biological studies of Nepeta asterotricha Rech. f. (Lamiaceae): Isolation of Nepetamoside / Mostafa Goldansaz, Seyed; Festa, Carmen; Pagano, Ester; DE MARINO, Simona; Finamore, Claudia; Parisi, OLGA ALESSANDRA; Borrelli, Francesca; Sonboli, Ali; D'Auria, MARIA VALERIA. - In: MOLECULES. - ISSN 1420-3049. - 24:9(2019), pp. 1684-1695. [10.3390/molecules24091684]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/752554
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