Transient-anomalous diffusion (tAD) has previously been used for tumor delineation and human brain tissue characterization, however, comparison with histology is largely missing. This work aims to compare α and γ tAD parameters, DTI and q-space-imaging parameters obtained at 9.4T with micro-MRI, with the morphologic characteristics provided by optical microscopy of mouse spinal cord white matter (MSC-wm). We found that γ- and q-space-imaging are sensitive to axon diameter and effective local axon density, while α-imaging is sensitive to the heterogeneity or degree of disorder of the wm tracts. These techniques outperform DTI as a means to probe MSC-wm morphology.

Transient anomalous diffusion micro-MRI parameters reflect white matter morphology: comparison with histology of the mouse spinal cord.

Bice Avallone
Membro del Collaboration Group
;
2018

Abstract

Transient-anomalous diffusion (tAD) has previously been used for tumor delineation and human brain tissue characterization, however, comparison with histology is largely missing. This work aims to compare α and γ tAD parameters, DTI and q-space-imaging parameters obtained at 9.4T with micro-MRI, with the morphologic characteristics provided by optical microscopy of mouse spinal cord white matter (MSC-wm). We found that γ- and q-space-imaging are sensitive to axon diameter and effective local axon density, while α-imaging is sensitive to the heterogeneity or degree of disorder of the wm tracts. These techniques outperform DTI as a means to probe MSC-wm morphology.
File in questo prodotto:
File Dimensione Formato  
ASCaporale_ISMRM_final(1).pdf

solo utenti autorizzati

Tipologia: Documento in Post-print
Licenza: Accesso privato/ristretto
Dimensione 956.16 kB
Formato Adobe PDF
956.16 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/746251
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact