Butyric acid (BUT), a short chain fatty acid produced daily by the gut microbiota, has proven beneficial in models of cardiovascular diseases. With advancements in cancer survival, an increasing number of patients are at risk of anticancer drug cardiotoxicity. Here we assess whether the novel BUT derivative phenylalanine-butyramide (FBA) protects from doxorubicin (DOXO) cardiotoxicity, by decreasing oxidative stress and improving mitochondrial function.
The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity / Russo, Michele; Guida, Fiorentina; Paparo, Lorella; Trinchese, Giovanna; Aitoro, Rosita; Avagliano, Carmen; Fiordelisi, Antonella; Napolitano, Fabiana; Mercurio, Valentina; Sala, Valentina; Li, Mingchuan; Sorriento, Daniela; Ciccarelli, Michele; Ghigo, Alessandra; Hirsch, Emilio; Bianco, Roberto; Iaccarino, Guido; Abete, Pasquale; Bonaduce, Domenico; Calignano, Antonio; Berni Canani, Roberto; Tocchetti, Carlo G. - In: EUROPEAN JOURNAL OF HEART FAILURE. - ISSN 1388-9842. - (2019), pp. 519-528. [10.1002/ejhf.1439]
The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity
Paparo, Lorella;Trinchese, Giovanna;Aitoro, Rosita;Avagliano, Carmen;Fiordelisi, Antonella;Napolitano, Fabiana;Mercurio, Valentina;Sorriento, Daniela;Ciccarelli, Michele;Bianco, Roberto;Iaccarino, Guido;Abete, Pasquale;Bonaduce, Domenico;Calignano, Antonio;Berni Canani, Roberto;Tocchetti, Carlo G
2019
Abstract
Butyric acid (BUT), a short chain fatty acid produced daily by the gut microbiota, has proven beneficial in models of cardiovascular diseases. With advancements in cancer survival, an increasing number of patients are at risk of anticancer drug cardiotoxicity. Here we assess whether the novel BUT derivative phenylalanine-butyramide (FBA) protects from doxorubicin (DOXO) cardiotoxicity, by decreasing oxidative stress and improving mitochondrial function.| File | Dimensione | Formato | |
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