OBJECTIVES: Early-onset preeclampsia is a form of preeclampsia requiring delivery before 34 weeks of gestation. The etiology is unknown, but placental dysfunction appears crucial. We evaluated the immunohistochemical expression of the antiapoptotic protein Bcl-2, the angiogenetic factors VEGF and PlGF, and the epithelial factors HGF, c-Met and STAT3 in placental samples of pregnancies complicated by early-onset preeclampsia. MATERIALS AND METHODS: Placental sections were obtained from 41 women with early-onset preeclampsia (cases) and from 31 uncomplicated pregnancies (controls). A standard haematoxylin and eosin stain was used to assess histological structure. Immunohistochemical expression of Bcl-2, VEGF, PlGF, HGF, c-Met and STAT3 was analyzed. RESULTS: Mean gestational age was 32 weeks in cases and 39 weeks in controls. Microscopically, sections from women with preeclampsia showed a disorder of villous development as a distal villous hypoplasia with placental undergrowth. The immunoistochemical expression of Bcl-2 (p < 0.0001), VEGF (p = 0.0323), PlGF (p = 0.002), HGF (p < 0.0001), c-Met (p < 0.0001) and STAT3 (p = 0.0004) were significantly lower in placentas of complicated pregnancies compared to uncomplicated ones. CONCLUSIONS: Early-onset preeclampsia is associated with a disorder of villous development. Apoptotic, angiogenetic and epithelial mechanisms are simultaneously impaired and contribute to placental dysfunctions.

Placental morphology, apoptosis, angiogenesis and epithelial mechanisms in early-onset preeclampsia / Travaglino, Antonio; Raffone, Antonio; Saccone, Gabriele; Migliorini, Sonia; Maruotti, Giuseppe Maria; Esposito, Gennaro; Mollo, Antonio; Martinelli, Pasquale; Zullo, Fulvio; D'Armiento, Maria. - In: EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY. - ISSN 0301-2115. - 234:(2019), pp. 200-206. [10.1016/j.ejogrb.2018.12.039]

Placental morphology, apoptosis, angiogenesis and epithelial mechanisms in early-onset preeclampsia

Travaglino, Antonio;Raffone, Antonio;Saccone, Gabriele;MIGLIORINI, SONIA;Maruotti, Giuseppe Maria;Mollo, Antonio;Martinelli, Pasquale;Zullo, Fulvio;D'Armiento, Maria
2019

Abstract

OBJECTIVES: Early-onset preeclampsia is a form of preeclampsia requiring delivery before 34 weeks of gestation. The etiology is unknown, but placental dysfunction appears crucial. We evaluated the immunohistochemical expression of the antiapoptotic protein Bcl-2, the angiogenetic factors VEGF and PlGF, and the epithelial factors HGF, c-Met and STAT3 in placental samples of pregnancies complicated by early-onset preeclampsia. MATERIALS AND METHODS: Placental sections were obtained from 41 women with early-onset preeclampsia (cases) and from 31 uncomplicated pregnancies (controls). A standard haematoxylin and eosin stain was used to assess histological structure. Immunohistochemical expression of Bcl-2, VEGF, PlGF, HGF, c-Met and STAT3 was analyzed. RESULTS: Mean gestational age was 32 weeks in cases and 39 weeks in controls. Microscopically, sections from women with preeclampsia showed a disorder of villous development as a distal villous hypoplasia with placental undergrowth. The immunoistochemical expression of Bcl-2 (p < 0.0001), VEGF (p = 0.0323), PlGF (p = 0.002), HGF (p < 0.0001), c-Met (p < 0.0001) and STAT3 (p = 0.0004) were significantly lower in placentas of complicated pregnancies compared to uncomplicated ones. CONCLUSIONS: Early-onset preeclampsia is associated with a disorder of villous development. Apoptotic, angiogenetic and epithelial mechanisms are simultaneously impaired and contribute to placental dysfunctions.
2019
Placental morphology, apoptosis, angiogenesis and epithelial mechanisms in early-onset preeclampsia / Travaglino, Antonio; Raffone, Antonio; Saccone, Gabriele; Migliorini, Sonia; Maruotti, Giuseppe Maria; Esposito, Gennaro; Mollo, Antonio; Martinelli, Pasquale; Zullo, Fulvio; D'Armiento, Maria. - In: EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY. - ISSN 0301-2115. - 234:(2019), pp. 200-206. [10.1016/j.ejogrb.2018.12.039]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/740327
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