The airway epithelium controls the chemical and physical properties of airway surface fluid and consequently mucociliary clearance. The treatment for 24-48 hours of human bronchial epithelial cells with interferon-gamma or interleukin-4 leads to marked changes in transepithelial ion transport properties. Both cytokines downregulate the activity of the epithelial Na+ channel and, at the same time, upregulate Ca2+-dependent Cl- secretion. Interleukin-4 also increases the expression and function of the cystic fibrosis transmembrane conductance regulator Cl- channel. These results suggest that some inflammatory stimuli may change the balance between fluid absorption and secretion to favor hydration of the airway surface and consequently mucus clearance.
Effect of inflammatory stimuli on airway ion transport / Galietta, Luis J V; Folli, Chiara; Caci, Emanuela; Pedemonte, Nicoletta; Taddei, Alessandro; Ravazzolo, Roberto; Zegarra-Moran, Olga. - In: PROCEEDINGS OF THE AMERICAN THORACIC SOCIETY. - ISSN 1546-3222. - 1:1(2004), pp. 62-65. [10.1513/pats.2306017]
Effect of inflammatory stimuli on airway ion transport
Galietta, Luis J V;TADDEI, ALESSANDRO;
2004
Abstract
The airway epithelium controls the chemical and physical properties of airway surface fluid and consequently mucociliary clearance. The treatment for 24-48 hours of human bronchial epithelial cells with interferon-gamma or interleukin-4 leads to marked changes in transepithelial ion transport properties. Both cytokines downregulate the activity of the epithelial Na+ channel and, at the same time, upregulate Ca2+-dependent Cl- secretion. Interleukin-4 also increases the expression and function of the cystic fibrosis transmembrane conductance regulator Cl- channel. These results suggest that some inflammatory stimuli may change the balance between fluid absorption and secretion to favor hydration of the airway surface and consequently mucus clearance.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
