Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Kappos, Ludwig;Bar-Or, Amit;Cree, Bruce A C;Fox, Robert J;Giovannoni, Gavin;Gold, Ralf;Vermersch, Patrick;Arnold, Douglas L;Arnould, Sophie;Scherz, Tatiana;Wolf, Christian;Wallström, Erik;Dahlke, Frank;Achiron, Anat;Achtnichts, Lutz;Agan, Kadriye;Akman-Demir, Gulsen;Allen, Alison B;Antel, Jack P;Antiguedad, Alfredo Rodriguez;Apperson, Michelle;Applebee, Angela M;Ayuso, Guillermo Izquierdo;Baba, Masayuki;Bajenaru, Ovidiu;Balasa, Rodica;Balci, Belgin Petek;Barnett, Michael;Bass, Ann;Becker, Veit U;Bejinariu, Mihaela;Bergh, Florian Then;Bergmann, Arnfin;Bernitsas, Evanthia;Berthele, Achim;Bhan, Virender;Bischof, Felix;Bjork, Randall John;Blevins, Gregg;Boehringer, Matthias;Boerner, Thomas;Bonek, Robert;Bowen, James D;Bowling, Allen;Boyko, Alexey N;Boz, Cavit;Bracknies, Vera;Braune, Stefan;Brescia Morra, Vincenzo;Brochet, Bruno;Brola, Waldemar;Brownstone, Paul Kenneth;Brozman, Miroslav;Brunet, Donald;Buraga, Ioan;Burnett, Margaret;Buttmann, Mathias;Butzkueven, Helmut;Cahill, Jonathan;Calkwood, Jonathan C;Camu, William;Cascione, Mark;Castelnovo, Giovani;Centonze, Diego;Cerqueira, Joao;Chan, Andrew;Cimprichova, Andrea;Cohan, Stanley;Comi, Giancarlo;Conway, Jill;Cooper, Joanna A;Corboy, John;Correale, Jorge;Costell, Brian;Cottrell, David A;Coyle, Patricia K;Craner, Matthew;Cui, Liying;Cunha, Luis;Czlonkowska, Anna;da Silva, Ana Martins;de Sa, Joao;de Seze, Jérôme;Debouverie, Marc;Debruyne, Jan;Decoo, Danny;Defer, Gilles;Derfuss, Tobias;Deri, Norma H;Dihenia, Bhupesh;Dioszeghy, Peter;Donath, Vladimir;Dubois, Benedicte;Duddy, Martin;Duquette, Pierre;Edan, Gilles;Efendi, Husnu;Elias, Stanton;Emrich, Peter J;Estruch, Bonaventura Casanova;Evdoshenko, Evgeniy P;Faiss, Juergen;Fedyanin, Alexander S;Feneberg, Wolfgang;Fermont, Jiske;Fernandez, Oscar Fernandez;Ferrer, Francisco Coret;Fink, Katharina;Ford, Helen;Ford, Corey;Francia, Ada;Freedman, Mark;Frishberg, Benjamin;Galgani, Simonetta;Garmany, George P;Gehring, Klaus;Gitt, Jeffrey;Gobbi, Claudio;Goldstick, Lawrence P;Gonzalez, Rafael Arroyo;Grandmaison, Francois;Grigoriadis, Nikolaos;Grigorova, Olga;Grimaldi, Luigi Maria Edoardo;Gross, Jeffrey;Gross-Paju, Katrin;Gudesblatt, Mark;Guillaume, Daniel;Haas, Judith;Hancinova, Viera;Hancu, Anca;Hardiman, Orla;Harmjanz, Arndt;Heidenreich, Fedor R;Hengstman, G J D;Herbert, Joseph;Herring, Mark;Hodgkinson, Suzanne;Hoffmann, Olaf M;Hofmann, Werner E;Honeycutt, William D;Hua, Le Hanh;Huang, Dehui;Huang, Yining;Huang, DeRen;Hupperts, Raymond;Imre, Piroska;Jacobs, Alan Keith;Jakab, Gabor;Jasinska, Elzbieta;Kaida, Kenichi;Kalnina, Jolanta;Kaprelyan, Ara;Karelis, Guntis;Karussis, Dimitrios;Katz, Amos;Khabirov, Farit A;Khatri, Bhupendra;Kimura, Takashi;Kister, Ilya;Kizlaitiene, Rasa;Klimova, Eleonora;Koehler, Juergen;Komatineni, Aparna;Kornhuber, Anselm;Kovacs, Krisztina;Koves, Agnes;Kozubski, Wojciech;Krastev, Georgi;Krupp, Lauren B;Kurca, Egon;Lassek, Christoph;Laureys, Guy;Lee, Liesly;Lensch, Eckart;Leutmezer, Fritz;Li, Hongzeng;Linker, Ralf A;Linnebank, Michael;Liskova, Petra;Llanera, Cristina;Lu, Jiahong;Lutterotti, Andreas;Lycke, Jan;Macdonell, Richard;Maciejowski, Maciej;Maeurer, Mathias;Magzhanov, Rim V;Maida, Eva-Maria;Malciene, Lina;Mao-Draayer, Yang;Marfia, Girolama Alessandra;Markowitz, Clyde;Mastorodimos, Vasileios;Matyas, Klotild;Meca-Lallana, Jose;Merino, Juan Antonio Garcia;Mihetiu, Ioan Gheorghe;Milanov, Ivan;Miller, Aaron E;Millers, Andrejs;Mirabella, Massimiliano;Mizuno, Masanori;Montalban, Xavier;Montoya, Lilina;Mori, Masahiro;Mueller, Stefanie;Nakahara, Jin;Nakatsuji, Yuji;Newsome, Scott;Nicholas, Richard;Nielsen, A Scott;Nikfekr, Esmaeil;Nocentini, Ugo;Nohara, Chiyoko;Nomura, Kyoichi;Odinak, Miroslav M;Olsson, Tomas;van Oosten, B W;Oreja-Guevara, Celia;Oschmann, Patrick;Overell, James;Pachner, Andrew;Panczel, Gyula;Pandolfo, Massimo;Papeix, Caroline;Patrucco, Liliana;Pelletier, Jean;Piedrabuena, Raul;Pless, Misha;Polzer, Udo;Pozsegovits, Krisztian;Rastenyte, Daiva;Rauer, Sebastian;Reifschneider, Gerd;Rey, Roberto;Rizvi, Syed A;Robertson, Derrick;Rodriguez, Jose Martinez;Rog, David;Roshanisefat, Homayoun;Rowe, Vernon;Rozsa, Csilla;Rubin, Susan;Rusek, Stanislaw;Saccà, Francesco;Saida, Takahiko;Salgado, Antonio Vasco;Sanchez, Victoria Eugenia Fernandez;Sanders, Kalina;Satori, Maria;Sazonov, Denis V;Scarpini, Elio Angelo;Schlegel, Eugen;Schluep, Myriam;Schmidt, Stephan;Scholz, Erich;Schrijver, H M;Schwab, Matthias;Schwartz, Raymond;Scott, James;Selmaj, Krzysztof;Shafer, Stuart;Sharrack, Basil;Shchukin, Ivan A;Shimizu, Yuko;Shotekov, Penko;Siever, Arno;Sigel, Karl-Otto;Silliman, Scott;Simo, Magdolna;Simu, Mihaela;Sinay, Vladimiro;Siquier, Antonio Escartin;Siva, Aksel;Skoda, Ondrej;Solomon, Andrew;Stangel, Martin;Stefoski, Dusan;Steingo, Brian;Stolyarov, Igor D;Stourac, Pavel;Strassburger-Krogias, Katrin;Strauss, Erik;Stuve, Olaf;Tarnev, Ivaylo;Tavernarakis, Antonios;Tello, Cristina Ramo;Terzi, Murat;Ticha, Veronika;Ticmeanu, Marina;Tiel-Wilck, Klaus;Toomsoo, Toomas;Tubridy, Niall;Tullman, Mark J;Tumani, Hayrettin;Turcani, Peter;Turner, Ben;Uccelli, Antonio;Urtaza, Francisco Javier Olascoaga;Vachova, Marta;Valikovics, Attila;Walter, Silke;Van Wijmeersch, Bart;Vanopdenbosch, Ludo;Weber, Joerg R;Weiss, Sara;Weissert, Robert;Vermersch, Patrick;West, Timothy;Wiendl, Heinz;Wiertlewski, Sandrine;Wildemann, Brigitte;Willekens, Barbara;Visser, L H;Vorobeychik, Galina;Xu, Xianhao;Yamamura, Takashi;Yang, Yi N;Yelamos, Sergio Martinez;Yeung, Michael;Zacharias, Alan;Zelkowitz, Marvin;Zettl, Uwe;Zhang, Meini;Zhou, Hongyu;Zieman, Ulf;Ziemssen, Tjalf

2018