The implementation of neural network models enables to reproduce com- plex biological phenomena. The tuning of a large number of biological parameters and synaptic mechanisms of several dierent cells that belong to a model is a very critical issue. In this work, we present the eects of increasing cAMP Response Element Binding protein (CREB)-dependent transcription on the storage and recall processes in CA1 microcircuit of the hippocampus, and we describe how parallel tools can be adopted to simulate biological behaviours experimentally observed. Here, we resort to a parallel computing strategy in order to achieve ecient and reliable simulations.
Analysis, Tuning and Implementation of a Hippocampal CA1 Microcircuit / Cuomo, Salvatore; De Michele, Pasquale; Galletti, Ardelio. - 1:(2017), pp. 249-270. [10.1142/9789814759717_0022]
Analysis, Tuning and Implementation of a Hippocampal CA1 Microcircuit
CUOMO, SALVATORE;
2017
Abstract
The implementation of neural network models enables to reproduce com- plex biological phenomena. The tuning of a large number of biological parameters and synaptic mechanisms of several dierent cells that belong to a model is a very critical issue. In this work, we present the eects of increasing cAMP Response Element Binding protein (CREB)-dependent transcription on the storage and recall processes in CA1 microcircuit of the hippocampus, and we describe how parallel tools can be adopted to simulate biological behaviours experimentally observed. Here, we resort to a parallel computing strategy in order to achieve ecient and reliable simulations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
