IBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase-isomaltase deficiency (CSID) is a rare genetic form of disaccharide malabsorption characterised by diarrhoea, abdominal pain and bloating, which are features common to IBS. We tested sucrase-isomaltase (SI) gene variants for their potential relevance in IBS.
Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome / Henström, Maria; Diekmann, Lena; Bonfiglio, Ferdinando; Hadizadeh, Fatemeh; Kuech, Eva Maria; von Köckritz Blickwede, Maren; Thingholm, Louise B; Zheng, Tenghao; Assadi, Ghazaleh; Dierks, Claudia; Heine, Martin; Philipp, Ute; Distl, Ottmar; Money, Mary E; Belheouane, Meriem; Heinsen, Femke Anouska; Rafter, Joseph; Nardone, GERARDO ANTONIO PIO; Cuomo, Rosario; Usai Satta, Paolo; Galeazzi, Francesca; Neri, Matteo; Walter, Susanna; Simrén, Magnus; Karling, Pontus; Ohlsson, Bodil; Schmidt, Peter T; Lindberg, Greger; Dlugosz, Aldona; Agreus, Lars; Andreasson, Anna; Mayer, Emeran; Baines, John F; Engstrand, Lars; Portincasa, Piero; Bellini, Massimo; Stanghellini, Vincenzo; Barbara, Giovanni; Chang, Lin; Camilleri, Michael; Franke, Andre; Naim, Hassan Y; D'Amato, Mauro. - In: GUT. - ISSN 0017-5749. - (2018), p. gutjnl-2016-312456. [10.1136/gutjnl-2016-312456]
Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome
Bonfiglio, Ferdinando;NARDONE, GERARDO ANTONIO PIO;CUOMO, ROSARIO;
2018
Abstract
IBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase-isomaltase deficiency (CSID) is a rare genetic form of disaccharide malabsorption characterised by diarrhoea, abdominal pain and bloating, which are features common to IBS. We tested sucrase-isomaltase (SI) gene variants for their potential relevance in IBS.| File | Dimensione | Formato | |
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2016 - Functional variants in the sucrase–isomaltase gene in IBS Gut-2016.pdf
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