This chapter describes the development and application of mass spectrometric strategies for solving structural problems, that are seeking to define the biological roles that carbohydrates play in health and disease. This approach has implications not only for understanding how sugar-coded recognition occurs, but also, because the sugar chains are so effective in stimulating immune responses, for the design of new drugs and vaccines, for example against parasites and pathogens. In particular, some mass spectrometry approaches are described for the carbohydrate moieties of glycoproteins, glycolipids and glycosaminoglycans.
Mass Spectroscopy: Updates in the Elucidation of Structure of Oligosaccharides (Chapter 4) in Carbohydrate Chemistry: State of the Art and Challenges for Drug Development (Editor Laura Cipolla) / Corsaro, MARIA MICHELA. - (2015), pp. 93-119. [10.1142/9781783267200_0004]
Mass Spectroscopy: Updates in the Elucidation of Structure of Oligosaccharides (Chapter 4) in Carbohydrate Chemistry: State of the Art and Challenges for Drug Development (Editor Laura Cipolla)
CORSARO, MARIA MICHELA
2015
Abstract
This chapter describes the development and application of mass spectrometric strategies for solving structural problems, that are seeking to define the biological roles that carbohydrates play in health and disease. This approach has implications not only for understanding how sugar-coded recognition occurs, but also, because the sugar chains are so effective in stimulating immune responses, for the design of new drugs and vaccines, for example against parasites and pathogens. In particular, some mass spectrometry approaches are described for the carbohydrate moieties of glycoproteins, glycolipids and glycosaminoglycans.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.