Tumor cells communicate with the cells of their microenvironment via a series of molecular and cellular interactions to aid their progression to a malignant state and ultimately their metastatic spread. Of the cells in the microenvironment with a key role in cancer development, tumor associated macrophages (TAMs) are among the most notable. Tumor cells release a range of chemokines, cytokines and growth factors to attract macrophages, and these in turn release numerous factors (e.g. VEGF, MMP-9 and EGF) that are implicated in invasion-promoting processes such as tumor cell growth, flicking of the angiogenic switch and immunosuppression (Rogers and Holen, J Transl Med 9:177, 2011)
Molecular determinants of cancer-related inflammation / Staibano, Stefania. - (2013), pp. 45-56. [10.1007/978-94-007-7149-9_2]
Molecular determinants of cancer-related inflammation
STAIBANO, STEFANIA
2013
Abstract
Tumor cells communicate with the cells of their microenvironment via a series of molecular and cellular interactions to aid their progression to a malignant state and ultimately their metastatic spread. Of the cells in the microenvironment with a key role in cancer development, tumor associated macrophages (TAMs) are among the most notable. Tumor cells release a range of chemokines, cytokines and growth factors to attract macrophages, and these in turn release numerous factors (e.g. VEGF, MMP-9 and EGF) that are implicated in invasion-promoting processes such as tumor cell growth, flicking of the angiogenic switch and immunosuppression (Rogers and Holen, J Transl Med 9:177, 2011)I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
