Several sets of ligands acting as antagonists at muscarinic receptor sites are considered by means of QSAR approach. Although the confusing role of the collinearity among vectors associated with physicochemical parameters makes it sometimes difficult to evaluate the quality of structure‐activity correlations, the points discussed in the paper are to draw attention to the development of correlations between biological affinity constants and structural features of antagonists. The results obtained are compared to those relative to an analogous study on the agonists. It is shown that correlation equations are essential for deriving refined concepts on the topology of muscarinic receptor sites. Copyright © 1992 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
A QSAR approach to the study of structural requirements of muscarinic receptor ligands. Part II: Antagonists / Pratesi, P; Caliendo, Giuseppe; Silipo, C.; Vittoria, A.. - In: QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS. - ISSN 0931-8771. - 11:2(1992), pp. 151-161. [10.1002/qsar.19920110205]
A QSAR approach to the study of structural requirements of muscarinic receptor ligands. Part II: Antagonists
CALIENDO, GIUSEPPE;
1992
Abstract
Several sets of ligands acting as antagonists at muscarinic receptor sites are considered by means of QSAR approach. Although the confusing role of the collinearity among vectors associated with physicochemical parameters makes it sometimes difficult to evaluate the quality of structure‐activity correlations, the points discussed in the paper are to draw attention to the development of correlations between biological affinity constants and structural features of antagonists. The results obtained are compared to those relative to an analogous study on the agonists. It is shown that correlation equations are essential for deriving refined concepts on the topology of muscarinic receptor sites. Copyright © 1992 WILEY‐VCH Verlag GmbH & Co. KGaA, WeinheimI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
