Transcription factors (TFs) act downstream of the major signalling pathways functioning as master regulators of cell fate. Their activity is tightly regulated at the transcriptional, post-transcriptional and post-translational level. Proteins modifying TF activity are not easily identified by experimental high-throughput methods.

A reverse-engineering approach to dissect post-translational modulators of transcription factor's activity from transcriptional data

GAMBARDELLA, GENNARO;PELUSO, IVANA;BANSAL, MUKESH;DI BERNARDO, DIEGO;MEDINA SANABRIA, Diego Luis
2015

Abstract

Transcription factors (TFs) act downstream of the major signalling pathways functioning as master regulators of cell fate. Their activity is tightly regulated at the transcriptional, post-transcriptional and post-translational level. Proteins modifying TF activity are not easily identified by experimental high-throughput methods.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/613556
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