Automated screening approaches are able to rapidly identify a set of small molecules inducing a desired phenotype from large small-molecule libraries. However, the resulting set of candidate molecules is usually very diverse pharmacologically, thus little insight on the shared mechanism of action (MoA) underlying their efficacy can be gained.
Drug-set enrichment analysis: a novel tool to investigate drug mode of action / Napolitano, Francesco; Sirci, Francesco; Carrella, Diego; DI BERNARDO, Diego. - In: BIOINFORMATICS. - ISSN 1367-4803. - (2015), p. btv536. [10.1093/bioinformatics/btv536]
Drug-set enrichment analysis: a novel tool to investigate drug mode of action
DI BERNARDO, DIEGO
2015
Abstract
Automated screening approaches are able to rapidly identify a set of small molecules inducing a desired phenotype from large small-molecule libraries. However, the resulting set of candidate molecules is usually very diverse pharmacologically, thus little insight on the shared mechanism of action (MoA) underlying their efficacy can be gained.File in questo prodotto:
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