The present lecture will focus on neuroendocrine effects of endocrine disrupting chemicals (EDCs). Their effects imply the necessity to establish the pollution nature and magnitude; set objectives; consider the full range of endocrine disruption; determine environmental sustainable risk; assess specie reproductive health. Research helps shedding new light on the ecological and economic consequences of chemical pollution. Recent technological advances have driven rapid development of histological, biochemical and DNA-based methods designed to facilitate detection and monitoring reproductive health of soil and marine species and the health status of their environments. To address these aspects, the comparative endocrinology laboratories pay special attention to the steroid receptors, aromatase, vitellogenin as well to the reactive oxygen species, antioxidants under steroid control, DNA damage and repair etc. using non-invasive biomarkers. These tools promise to improve on traditional monitoring approaches by enhancing detection sensitivity, reducing analytical turnaround times and monitoring costs, and increasing specificity of target identifications. A "better safe than sorry" approach based on the precautionary principle should be taken when dealing with chemicals that may impact our son developing brain.

ENVIRONMENT AND CENTRAL NERVOUS SYSTEM (LECTURE)

GUERRIERO, GIULIA
2014

Abstract

The present lecture will focus on neuroendocrine effects of endocrine disrupting chemicals (EDCs). Their effects imply the necessity to establish the pollution nature and magnitude; set objectives; consider the full range of endocrine disruption; determine environmental sustainable risk; assess specie reproductive health. Research helps shedding new light on the ecological and economic consequences of chemical pollution. Recent technological advances have driven rapid development of histological, biochemical and DNA-based methods designed to facilitate detection and monitoring reproductive health of soil and marine species and the health status of their environments. To address these aspects, the comparative endocrinology laboratories pay special attention to the steroid receptors, aromatase, vitellogenin as well to the reactive oxygen species, antioxidants under steroid control, DNA damage and repair etc. using non-invasive biomarkers. These tools promise to improve on traditional monitoring approaches by enhancing detection sensitivity, reducing analytical turnaround times and monitoring costs, and increasing specificity of target identifications. A "better safe than sorry" approach based on the precautionary principle should be taken when dealing with chemicals that may impact our son developing brain.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/599635
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact