Phytochemical investigation of polar extract from Juniperus oxycedrus spp. oxycedrus berries leds to the isolation of one new monoterpene glucoside (1) along with seven known components, some of them were initially isolated from Juniperus communis. L. berries. Their structures were established on the basis of extensive 1D and 2D NMR and ESI-MS studies. The n-butanol fraction and isolated components, shikimic acid (2), compounds 3, 4 and 5 were evaluated, in vitro, for their effect on cell viability against human malignant melanoma (!375), breast (MCF-7) and lung (H460) cancer cell lines. Shikimic acid exhibited selective effect on cell viability only against breast MCF-7 cell lines reaching IC50 value at dose of 30microM and also induced the level decrease of vascular endothelial growth factor (VEGF) and five pro-inflammatory cytokines suggesting its potential anti-inflammatory effect.

Phytochemical profile of Juniperus oxycedrus ssp. oxycedrus berries: A new momoterpene glucoside and evaluation of the effects on cancer cell lines / DE MARINO, Simona; Festa, Carmen; Zollo, Franco; Fabiola, Rusolo; Francesca, Capone; Eliana, Guerriero; Susan, Costantini; Vincenzo de, Felice; Maria, Iorizzi. - In: PHYTOCHEMISTRY LETTERS. - ISSN 1874-3900. - 10:(2014), pp. 152-159. [10.1016/j.phytol.2014.08.015]

Phytochemical profile of Juniperus oxycedrus ssp. oxycedrus berries: A new momoterpene glucoside and evaluation of the effects on cancer cell lines

DE MARINO, SIMONA
Primo
;
FESTA, CARMEN
Secondo
;
ZOLLO, FRANCO;
2014

Abstract

Phytochemical investigation of polar extract from Juniperus oxycedrus spp. oxycedrus berries leds to the isolation of one new monoterpene glucoside (1) along with seven known components, some of them were initially isolated from Juniperus communis. L. berries. Their structures were established on the basis of extensive 1D and 2D NMR and ESI-MS studies. The n-butanol fraction and isolated components, shikimic acid (2), compounds 3, 4 and 5 were evaluated, in vitro, for their effect on cell viability against human malignant melanoma (!375), breast (MCF-7) and lung (H460) cancer cell lines. Shikimic acid exhibited selective effect on cell viability only against breast MCF-7 cell lines reaching IC50 value at dose of 30microM and also induced the level decrease of vascular endothelial growth factor (VEGF) and five pro-inflammatory cytokines suggesting its potential anti-inflammatory effect.
2014
Phytochemical profile of Juniperus oxycedrus ssp. oxycedrus berries: A new momoterpene glucoside and evaluation of the effects on cancer cell lines / DE MARINO, Simona; Festa, Carmen; Zollo, Franco; Fabiola, Rusolo; Francesca, Capone; Eliana, Guerriero; Susan, Costantini; Vincenzo de, Felice; Maria, Iorizzi. - In: PHYTOCHEMISTRY LETTERS. - ISSN 1874-3900. - 10:(2014), pp. 152-159. [10.1016/j.phytol.2014.08.015]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/585817
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