RET (rearranged during transfection) is a receptor tyrosine kinase involved in the development of neural crest derived cell lineages, kidney, and male germ cells. Different human cancers, including papillary and medullary thyroid carcinomas, lung adenocarcinomas, and myeloproliferative disorders display gain-of-function mutations in RET. Accordingly, RET protein has become a promising molecular target for cancer treatment.
Central role of RET in thyroid cancer / Santoro, Massimo; Carlomagno, Francesca. - In: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. - ISSN 1943-0264. - 5(12):a009233.:(2013). [10.1101/cshperspect.a009233.]
Central role of RET in thyroid cancer
SANTORO, MASSIMO;CARLOMAGNO, Francesca
2013
Abstract
RET (rearranged during transfection) is a receptor tyrosine kinase involved in the development of neural crest derived cell lineages, kidney, and male germ cells. Different human cancers, including papillary and medullary thyroid carcinomas, lung adenocarcinomas, and myeloproliferative disorders display gain-of-function mutations in RET. Accordingly, RET protein has become a promising molecular target for cancer treatment.File in questo prodotto:
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