Plakortides R-U, four new polyketide endoperoxides, have been isolated from the marine sponge Plakinastrella mamillaris. Their structures were elucidated on the basis of extensive NMR spectroscopic and MS analyses and by chemical methods. In addition, a new method for the unambiguous stereochemical elucidation of 3,6-disubstituted 1,2-dioxines, frequently isolated from Plakinidae sponges, is reported. Pharmacological analysis demonstrated that plakortide U is endowed with in vitro antiplasmodial activity against a chloroquine-resistant strain.
New antimalarial polyketide endoperoxides from the marine sponge Plakinastrella mamillaris collected at Fiji Islands / Festa, Carmen; DE MARINO, Simona; D'Auria, MARIA VALERIA; TAGLIALATELA SCAFATI, Orazio; E., Deharo; S., Petek; Zampella, Angela. - In: TETRAHEDRON. - ISSN 0040-4020. - 69:18(2013), pp. 3706-3713. [10.1016/j.tet.2013.03.006]
New antimalarial polyketide endoperoxides from the marine sponge Plakinastrella mamillaris collected at Fiji Islands
FESTA, CARMEN;DE MARINO, SIMONA;D'AURIA, MARIA VALERIA;TAGLIALATELA SCAFATI, ORAZIO;ZAMPELLA, ANGELA
2013
Abstract
Plakortides R-U, four new polyketide endoperoxides, have been isolated from the marine sponge Plakinastrella mamillaris. Their structures were elucidated on the basis of extensive NMR spectroscopic and MS analyses and by chemical methods. In addition, a new method for the unambiguous stereochemical elucidation of 3,6-disubstituted 1,2-dioxines, frequently isolated from Plakinidae sponges, is reported. Pharmacological analysis demonstrated that plakortide U is endowed with in vitro antiplasmodial activity against a chloroquine-resistant strain.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
