Mitochondrial Ca2+ Dysregulation During Stroke and Cell Death

This book illustrates remarkable roles of metal ions in the neuropathophysiology of stroke, which is a major cause of death and disability worldwide. Metal ions have unique chemical properties that allow them to play diverse roles in the brain. They regulate excitability and function as co-factors in cellular and genetic signaling pathways and therefore, have important roles ranging from essential to toxic. For the first time, the dyshomeostasis and pathophysiological actions of these metals in stroke are discussed systematically in thirty-six chapters in one volume.