Here we report the design, synthesis and biological assays of improved DNA-based inhibitors of HMGB1 cytokine activity, in which the previously studied kinked DNA duplexes were chemically modified ito give monomolecular analogues assembled into kinked hairpin-loop DNA structures.
Inhibition of cytokine activity by improved DNA-based ligands / Musumeci, Domenica; Roviello, Giovanni; Montesarchio, Daniela; Bucci, E. M.; Sapio, R.; Valente, M.; Anrò, V.. - (2012). (Intervento presentato al convegno Convegno Nazionale di Chimica dei Sistemi Biologici della SCI tenutosi a Napoli nel 24-25 setembre 2012).
Inhibition of cytokine activity by improved DNA-based ligands
MUSUMECI, DOMENICA;ROVIELLO, GIOVANNI;MONTESARCHIO, DANIELA;
2012
Abstract
Here we report the design, synthesis and biological assays of improved DNA-based inhibitors of HMGB1 cytokine activity, in which the previously studied kinked DNA duplexes were chemically modified ito give monomolecular analogues assembled into kinked hairpin-loop DNA structures.File in questo prodotto:
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