Pseudomonas chlororaphis subsp. aureofaciens strain M71 produced two phenazine compounds as main secondary metabolites. These metabolites were identified as phenazine-1-carboxylic acid (PCA) and 2-hydroxyphenazine (2-OH P). In this study, the spectrum of the activity of PCA and 2-OH P was evaluated against a group of crop and forestal plant pathogenic fungi by an agar plate bioassay. PCA was active against most of the tested plant pathogens, while 2-OH P slightly inhibited a few fungal species. Furthermore, four semisynthesised derivatives of PCA (phenazine-1-carboxymethyl, phenazine-1-carboxamide, phenazine-1-hydroxymethyl and phenazine-1-acetoxymethyl) were assayed for their antifungal activity against 11 phytopathogenic species. Results showed that the carboxyl group is a structural feature important for the antifungal activity of PCA. Since the activity of phenazine-1-carboxymethyl and phenazine-1- carboxamide, the two more lipophilic and reversible PCA derivatives remained substantially unaltered compared with PCA.

Insight on the susceptibility of plant pathogenic fungi to phenazine-1-carboxylic acid and its chemical derivatives / G., Puopolo; Masi, Marco; A., Raio; Andolfi, Anna; Zoina, Astolfo; Cimmino, Alessio; Evidente, Antonio. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - 27:(2013), pp. 956-966. [10.1080/14786419.2012.696257]

Insight on the susceptibility of plant pathogenic fungi to phenazine-1-carboxylic acid and its chemical derivatives

MASI, MARCO;ANDOLFI, ANNA;ZOINA, ASTOLFO;CIMMINO, ALESSIO;EVIDENTE, ANTONIO
2013

Abstract

Pseudomonas chlororaphis subsp. aureofaciens strain M71 produced two phenazine compounds as main secondary metabolites. These metabolites were identified as phenazine-1-carboxylic acid (PCA) and 2-hydroxyphenazine (2-OH P). In this study, the spectrum of the activity of PCA and 2-OH P was evaluated against a group of crop and forestal plant pathogenic fungi by an agar plate bioassay. PCA was active against most of the tested plant pathogens, while 2-OH P slightly inhibited a few fungal species. Furthermore, four semisynthesised derivatives of PCA (phenazine-1-carboxymethyl, phenazine-1-carboxamide, phenazine-1-hydroxymethyl and phenazine-1-acetoxymethyl) were assayed for their antifungal activity against 11 phytopathogenic species. Results showed that the carboxyl group is a structural feature important for the antifungal activity of PCA. Since the activity of phenazine-1-carboxymethyl and phenazine-1- carboxamide, the two more lipophilic and reversible PCA derivatives remained substantially unaltered compared with PCA.
2013
Insight on the susceptibility of plant pathogenic fungi to phenazine-1-carboxylic acid and its chemical derivatives / G., Puopolo; Masi, Marco; A., Raio; Andolfi, Anna; Zoina, Astolfo; Cimmino, Alessio; Evidente, Antonio. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - 27:(2013), pp. 956-966. [10.1080/14786419.2012.696257]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/507834
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