We report on tests of a radionuclide imaging system for in vivo investigations in small animals with low energy gamma-rays as from 125I (27-35 keV). The system imaging optics features a high resolution coded aperture mask and a fine pitch silicon hybrid pixel detector of the Medipix2 series (55 ?m pitch). The coded aperture (no-two-holes-touching MURA 62?62) had 70 ?m holes in 75 ?m tungsten, and was used in a 2:1 magnification for a field of view of about 7 mm. Laboratory tests with a 109Cd 22-keV source and in vivo mouse thyroid imaging tests with 125I show a system resolution of about 110 ?m. This low energy, semiconductor-based, compact gamma camera is the basic imaging unit of a small animal single photon emission computed tomography system with deep sub-millimeter resolution
Toward a Medipix2 coded aperture gamma microscope / Accorsi, R.; Autiero, M.; Celentano, L.; Cozzolino, R.; Laccetti, P.; Lanza, R. C.; Marotta, M.; Mettivier, G.; Montesi, M. C.; Riccio, P.; Roberti, G.; Russo, P.. - (2004). (Intervento presentato al convegno IEEE Nucl. Sci. Symp. and Medical Imaging Conference tenutosi a Roma nel Ottobre 16-22, 2004).
Toward a Medipix2 coded aperture gamma microscope
M. AUTIERO;L. CELENTANO;P. LACCETTI;M. MAROTTA;G. METTIVIER;M. C. MONTESI;P. RICCIO;G. ROBERTI;P. RUSSO
2004
Abstract
We report on tests of a radionuclide imaging system for in vivo investigations in small animals with low energy gamma-rays as from 125I (27-35 keV). The system imaging optics features a high resolution coded aperture mask and a fine pitch silicon hybrid pixel detector of the Medipix2 series (55 ?m pitch). The coded aperture (no-two-holes-touching MURA 62?62) had 70 ?m holes in 75 ?m tungsten, and was used in a 2:1 magnification for a field of view of about 7 mm. Laboratory tests with a 109Cd 22-keV source and in vivo mouse thyroid imaging tests with 125I show a system resolution of about 110 ?m. This low energy, semiconductor-based, compact gamma camera is the basic imaging unit of a small animal single photon emission computed tomography system with deep sub-millimeter resolutionI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
