Skin is provided ofanisotropic and non-linear elastic mechanical properties Sucli properties allow joints to move properly aiid protect iiiternal organs Sroni extemal rnechanical insults Skiii mechanical behaviour is coinplex and is strongly iiiiluenced by its iinique microstnicture and ECM composition Skin is indeed a multilayered strutture in which collagen forms ali upper feltwork of thin fibres (papillary layer) over a looser entangled mass of tliicker bundles (reticular layer). Individua1 collageii fibres arc surrounded by a glycosamrninoglycan reticulum, while the elastin network interpenetrates the collagen-gag stnicture. The aim of this work is to asses tlie effect of ECM macromolecules on the viscoelastic properties of dermis. Nieological experiments have been carried out on native bovine dermis, trypsin and elastase processed dermis. Samples have been splitted in the papillary-reticular ~iinctiona nd tested, in order to asses the relative influente of ECM inacrornolecules on the specific layer Storage and viscous moduli protiles stiggest that glvcosamminoglycan reticulum plays nn important role oli collageii fibres slippage The elastin nctwork is mainly responsible for early tissue response and elastic recoil
The effect of ECM macromolecules on the rheological behaviour of bovine dermis / Ventre, Maurizio; Netti, PAOLO ANTONIO; Mollica, F.. - (2006). (Intervento presentato al convegno FECTS XXth & ISMB meeting tenutosi a Oulu, Finlandia (SF) nel 1-5 Lugio, 2006).
The effect of ECM macromolecules on the rheological behaviour of bovine dermis
VENTRE, MAURIZIO;NETTI, PAOLO ANTONIO;
2006
Abstract
Skin is provided ofanisotropic and non-linear elastic mechanical properties Sucli properties allow joints to move properly aiid protect iiiternal organs Sroni extemal rnechanical insults Skiii mechanical behaviour is coinplex and is strongly iiiiluenced by its iinique microstnicture and ECM composition Skin is indeed a multilayered strutture in which collagen forms ali upper feltwork of thin fibres (papillary layer) over a looser entangled mass of tliicker bundles (reticular layer). Individua1 collageii fibres arc surrounded by a glycosamrninoglycan reticulum, while the elastin network interpenetrates the collagen-gag stnicture. The aim of this work is to asses tlie effect of ECM macromolecules on the viscoelastic properties of dermis. Nieological experiments have been carried out on native bovine dermis, trypsin and elastase processed dermis. Samples have been splitted in the papillary-reticular ~iinctiona nd tested, in order to asses the relative influente of ECM inacrornolecules on the specific layer Storage and viscous moduli protiles stiggest that glvcosamminoglycan reticulum plays nn important role oli collageii fibres slippage The elastin nctwork is mainly responsible for early tissue response and elastic recoilI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
