In this chapter, we are describing the biology of medulloblastoma influenced by several genes/pathways which concur to its pathogenesis. Of note, several levels of regulation are mediated by miRNAs functions, which we dissect their “state of art” to underline their crucial roles on controlling cancer development. In brain tumours, literatures data, are supporting the values of Cancer Stem Cells (tumor propagating cells) and their functions for tumour recurrence for future therapeutic treatments. Thus, we link the potential use of miRNAs as “shuttle” to impair Cancer Stem Cells in medulloblastoma.
MicroRNAs and Cancer Stem Cells in Medulloblastoma / Zollo, Massimo; Andolfo, Immacolata; DE ANTONELLIS, Pasqualino. - ELETTRONICO. - Capitolo 16:(2011), pp. 313-332. [10.5772/13911]
MicroRNAs and Cancer Stem Cells in Medulloblastoma
ZOLLO, MASSIMO;Immacolata Andolfo;Pasqualino De Antonellis
2011
Abstract
In this chapter, we are describing the biology of medulloblastoma influenced by several genes/pathways which concur to its pathogenesis. Of note, several levels of regulation are mediated by miRNAs functions, which we dissect their “state of art” to underline their crucial roles on controlling cancer development. In brain tumours, literatures data, are supporting the values of Cancer Stem Cells (tumor propagating cells) and their functions for tumour recurrence for future therapeutic treatments. Thus, we link the potential use of miRNAs as “shuttle” to impair Cancer Stem Cells in medulloblastoma.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
