Transglutaminase (TGase) activity was reduced in intact mitogen-stimulated human peripheral blood lymphocytes (PBL) when compared to intact resting PBL. Moreover, a treatment of the same quiescent immunocompetent cells with purified liver TGase and Ca2+ completely suppressed the mitogen-induced blast transformation. A decrease in TGase activity in neoplastically transformed seminal vesicle epithelial cells with respect to their normal parent counterpart was also observed. Our data support the notion of a possible implication of TGase in cell proliferation and transformation.
Transglutaminase in cell proliferation and transformation / Metafora, S; Peluso, G; Ravagnan, G; Marchese, M; Di Pietro, M; Mancini, A; Panza, N; Fusco, A; Porta, Raffaele. - In: MEDICAL ONCOLOGY AND TUMOR PHARMOCOTHERAPY. - ISSN 0736-0118. - STAMPA. - 5:(1988), pp. 223-231.
Transglutaminase in cell proliferation and transformation.
PORTA, RAFFAELE
1988
Abstract
Transglutaminase (TGase) activity was reduced in intact mitogen-stimulated human peripheral blood lymphocytes (PBL) when compared to intact resting PBL. Moreover, a treatment of the same quiescent immunocompetent cells with purified liver TGase and Ca2+ completely suppressed the mitogen-induced blast transformation. A decrease in TGase activity in neoplastically transformed seminal vesicle epithelial cells with respect to their normal parent counterpart was also observed. Our data support the notion of a possible implication of TGase in cell proliferation and transformation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
